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首页> 外文期刊>Proceeding of the Singapore National Academy of Science >Long Non-Coding RNAs in Melanoma Development and Biology
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Long Non-Coding RNAs in Melanoma Development and Biology

机译：长非编码rna在黑色素瘤和发展生物学

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摘要

Melanoma is the most aggressive and deadly type of skin cancer and presents a major clinical challenge due to its ability to rapidly metastasize and become resistant to immune and targeted therapies. The identification and characterization of new molecular targets and pathways involved in the initiation, progression, and maintenance of melanoma will be critical for the development of superior treatments. Long non-coding RNAs (IncRNAs), a class of non-coding RNAs involved in regulating numerous cellular processes including tumor progression, cancer cell metastasis, and resistance to anti-cancer therapies, may be viable therapeutic targets in melanoma. In this review, we describe IncRNAs that contribute to melanoma development through microRNA (miRNA) sponging, regulation of metabolism, modification of the epigen- ome, or modulation of pro-tumorigenic signaling pathways. While more work remains to be done to characterize IncRNAs in melanoma, gaining a better understanding of their functions promises to yield a wide range of possibilities to improve melanoma diagnosis, prognosis, and treatment.
机译：黑色素瘤是最激进的和致命的类型的一个主要临床皮肤癌和礼物挑战由于其迅速的能力免疫和转移并产生抗药性靶向治疗。新的分子靶点和表征通路参与了启动、进展和维护的黑色素瘤将至关重要优越的治疗方法的发展。非编码rna (IncRNAs),非编码的类rna参与调节许多细胞流程包括肿瘤恶化,癌症抗癌细胞转移和阻力治疗,可能是可行的治疗目标黑素瘤。这对黑色素瘤的发展作出贡献微rna (microRNA)骗取的监管新陈代谢,修改epigen分泌性中耳炎,或pro-tumorigenic调制的信号通路。而更多的工作有待完成描述IncRNAs在黑色素瘤,获得一个更好的理解其功能的承诺产生广泛的可能性提高黑色素瘤的诊断、预后和治疗。

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