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首页> 外文期刊>Human psychopharmacology: clinical and experimental >Efficacy and tolerability of quetiapine in patients with schizophrenia who switched from haloperidol, olanzapine or risperidone.
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Efficacy and tolerability of quetiapine in patients with schizophrenia who switched from haloperidol, olanzapine or risperidone.

机译：喹硫平的疗效和耐受性精神分裂症患者了氟哌啶醇、奥氮平、利培酮。

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摘要

A post hoc analysis of the SPECTRUM trial was carried out to evaluate whether the improvements in efficacy and tolerability gained on switching to quetiapine occurred consistently for patients previously treated with either: haloperidol (n = 43); olanzapine (n = 66); or risperidone (n = 55) monotherapy. Patients were initiated with quetiapine to 400 mg/day over 7 days, and then flexibly dosed (300-750 mg/day) for 11 weeks. The mean (SD) modal dose of quetiapine was 501 (138) mg/day in the haloperidol subgroup, 472 (147) mg/day in the olanzapine subgroup and 485 (141) mg/day in the risperidone subgroup at the study endpoint. Switching to quetiapine induced significant improvements from baseline in PANSS scores, with least square mean changes in total scores of -32.5, -15.4, and -18.5 for patients previously treated with haloperidol, olanzapine and risperidone, respectively, (all p < 0.001 vs baseline). Significant improvements were also noted in CDSS scores, particularly for patients clinically depressed at baseline (all p < 0.001 vs baseline). There were significant reductions in EPS on the SAS and BAS for all subgroups (all p < 0.001 vs baseline). Switching to quetiapine produced efficacy and tolerability benefits regardless of whether their previous antipsychotic was haloperidol, olanzapine or risperidone. Copyright (c) 2005 John Wiley & Sons, Ltd.
机译：的事后分析频谱审判评估是否进行改进在疗效和耐受性得到切换喹硫平发生持续的病人以前对待:氟哌啶醇(n =43);单一疗法。喹硫平7天超过400毫克/天,然后灵活前(300 - 750 mg /天)11周。意味着(SD)模态剂量喹硫平的501 (138)472毫克/天的氟哌啶醇组(147)奥氮平组和485毫克/天(141)毫克/天利培酮组的研究端点。显著改善数值的基线分数,与最小二乘法的意思是总量的变化得分为-32.5,-15.4和-18.5以前用氟哌啶醇治疗,奥氮平和利培酮(所有p < 0.001 vs基线)。在信用违约互换分数,尤其是病人临床抑郁在基线(所有p < 0.001与基线)。在EPS SAS和BAS子组(所有p < 0.001 vs基线)。产生的疗效和耐受性的好处不管他们之前抗精神病药物氟哌啶醇,奥氮平或利培酮。儿子,有限公司

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