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首页> 外文期刊>Archives of microbiology >Bacillus subtilis CinA is a stationary phase-induced protein that localizes to the nucleoid and plays a minor role in competent cells.
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Bacillus subtilis CinA is a stationary phase-induced protein that localizes to the nucleoid and plays a minor role in competent cells.

机译：枯草芽孢杆菌CinA是一种固定相诱导的蛋白质，其定位在核苷中，在感受态细胞中起次要作用。

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摘要

CinA is a conserved bacterial protein that has been reported to play an important role during competence in Streptococcus pneumoniae by recruiting the RecA protein to the cell membrane. Here, we provide information on the homologous CinA in Bacillus subtilis. We found that the synthesis of CinA is upregulated during stationary phase in all cells. The loss of CinA has a mild effect during competence, but it has no influence on the localization of RecA. CinA was observed to be associated with the nucleoid in the cell, and not with the cell membrane, as shown for S. pneumoniae. Purified CinA is a soluble protein, probably forming trimers, like other homologues, which share a domain with CinA that has been reported to be involved in molybdopterine biosynthesis. Our results suggest that CinA plays a nucleoid-associated general role in cells entering stationary phase that is not specific to competence in B. subtilis and possibly in many other bacteria.
机译：CinA是一种保守的细菌蛋白，据报道通过将RecA蛋白募集到细胞膜上，在肺炎链球菌的竞争中起着重要作用。在这里，我们提供了有关枯草芽孢杆菌中同源CinA的信息。我们发现，CinA的合成在所有细胞的稳定期均被上调。 CinA的丧失在竞争过程中有轻微影响，但对RecA的定位没有影响。如肺炎链球菌所示，观察到CinA与细胞中的核苷相关，而不与细胞膜相关。纯化的CinA是一种可溶性蛋白，可能像其他同源物一样形成三聚体，与CinA共享一个域，据报道该域参与了钼蝶呤的生物合成。我们的结果表明，CinA在进入稳定期的细胞中扮演着与类核苷酸相关的一般角色，而这对枯草芽孢杆菌和其他许多细菌的竞争能力不是特异性的。

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