...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Toxicology >Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice.
【24h】

Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice.

机译：在Fischer 344 / N大鼠和B6C3F1小鼠的2和4-甲基咪唑的14周毒性研究中，诱导了甲状腺病变。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Fifteen-day and 14-week studies of 2-methylimidazole (2MI) and 4-methylimidazole (4MI) were conducted because of widespread human exposure via ingestion of food products containing the compounds and lack of toxicity data. Groups of five male and five female Fischer rats and B6C3F1 mice were administered 2MI by dosed feed at 0, 1,200, 3,300, or 10,000 ppm or 4MI at 0, 300, 800, or 2,500 ppm for 15 days, and groups of 10 male and 10 female Fischer rats and B6C3F1 mice were administered 2MI or 4MI at 0, 625, 1,250, 2,500, 5,000 or 10,000 ppm for 14 weeks. In the 15-day studies, 2MI induced thyroid follicular-cell hyperplasia and pituitary pars-distalis hypertrophy in rats and thyroid follicular-cell hypertrophy and spleen hematopoietic-cell proliferation in mice; 4MI induced no histopathological changes in rats and mice. In the 14-week studies, 2MI increased concentrations of thyroid-stimulating hormone (TSH) and decreased those of thyroxine (T(4)) and triiodothyroxine (T(3)) in male and female rats according to the dosage. Incidences of diffuse follicular-cell hyperplasia of the thyroid gland increased significantly in male rats exposed to 1,250 ppm or greater and female rats exposed to 2,500 ppm or greater. Thyroid follicular-cell adenoma was diagnosed in two males in the 10,000-ppm group. A dose-related anemia occurred in female rats. In mice, follicular-cell hypertrophy of the thyroid gland, anemia, splenic hematopoietic-cell proliferation, and hemosiderin in kidney tubules appeared. In rats, 4MI induced tremors and ataxia in the high-dose groups. Serum T(3), T(4), and TSH levels were not altered, and no thyroid lesions occurred. Anemia, hepatocytic vacuolation, testicular degeneration, and prostatic atrophy were observed. In mice, anemia, liver cytoplasmic vacuolization, and renal degeneration and dilation occurred. Our studies demonstrated that, in rats and mice, 2MI induces thyroid hyperplasia and hypertrophy, and both 2MI and 4MI induce anemia; 2MI induces thyroid follicular-cell adenoma in male rats.
机译：进行2-甲基咪唑（2MI）和4-甲基咪唑（4MI）的15天和14周研究是因为人类通过摄入含有该化合物的食品而广泛暴露于该物质，并且缺乏毒性数据。分别给5只雄性和5只雌性Fischer大鼠和B6C3F1小鼠组2MI，分别以0、1,200、3,300或10,000 ppm的剂量喂食2MI，或以0、300、800或2,500 ppm的4MI喂15天，每组10只向10只雌性Fischer大鼠和B6C3F1小鼠分别以0、625、1,250、2,500、5,000或10,000 ppm的2MI或4MI给药14周。在为期15天的研究中，2MI诱导了大鼠甲状腺滤泡细胞增生和垂体pars-distalis肥大，而小鼠甲状腺滤泡细胞肥大和脾造血细胞增殖; 4MI在大鼠和小鼠中未引起组织病理学改变。在14周的研究中，根据剂量，2MI可增加雄性和雌性大鼠甲状腺刺激激素（TSH）的浓度，并降低甲状腺素（T（4））和三碘甲状腺素（T（3））的浓度。暴露于1,250 ppm或更高的雄性大鼠和暴露于2,500 ppm或更高的雌性大鼠，甲状腺弥漫性滤泡细胞增生的发生率显着增加。在10,000 ppm组中，两名男性被诊断出甲状腺滤泡细胞腺瘤。雌性大鼠发生剂量相关性贫血。在小鼠中，出现了甲状腺的滤泡细胞肥大，贫血，脾造血细胞增殖和肾小管中的铁血黄素。在大鼠中，高剂量组4MI会引起震颤和共济失调。血清T（3），T（4）和TSH水平未改变，且未发生甲状腺病变。观察到贫血，肝细胞空泡，睾丸变性和前列腺萎缩。在小鼠中，发生贫血，肝细胞质空泡化以及肾脏变性和扩张。我们的研究表明，在大鼠和小鼠中，2MI引起甲状腺增生和肥大，2MI和4MI均引起贫血。 2MI诱发雄性大鼠甲状腺滤泡细胞腺瘤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号