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首页> 外文期刊>Arteriosclerosis, thrombosis, and vascular biology >Role of vessel wall and bone marrow syndecan-4 in neointimal hyperplasia: the plot thickens.
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Role of vessel wall and bone marrow syndecan-4 in neointimal hyperplasia: the plot thickens.

机译：血管壁和骨髓syndecan-4在新内膜增生中的作用：情节增厚。

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摘要

Syndecan 4 (Syn4) is 1 of a family of 4 transmembrane heparan sulfate proteoglycans found in mammals. An evolutionary conserved cytoplasmic domain on syndecans supports a key role for cell surface ligand binding and cytoplasmic signaling. Along with integrins, syndecans serve as key structural elements in concentrating ligands on the cell surface. To date, a multiplicity of functions have been ascribed to syndecans, including growth factor tethering in the extracellular matrix (ECM) and cytoplasmic signaling, which activates focal adhesion, cytoskeletal reorganization, and metalloproteinase activation. Syndecans have previously been noted for their ECM sensing and thrombin binding properties in the context of tissue injury and repair, and they perform a key role in regulating basic fibroblast growth factor and platelet-derived growth factor-induced smooth muscle cell (SMC) signaling events supporting activation and regulation of SMC responses to vascular injury.
机译：Syndecan 4（Syn4）是在哺乳动物中发现的4个跨膜硫酸乙酰肝素蛋白聚糖家族中的1个。 Syndecans上的进化保守的胞质结构域支持细胞表面配体结合和胞质信号传导的关键作用。与整联蛋白一起，聚癸二烯充当浓缩细胞表面上的配体的关键结构要素。迄今为止，syndecan具有多种功能，包括细胞外基质（ECM）中的生长因子束缚和细胞质信号传导，它们激活粘着斑，细胞骨架重组和金属蛋白酶活化。 Syndecans先前因在组织损伤和修复过程中的ECM感应和凝血酶结合特性而闻名，它们在调节碱性成纤维细胞生长因子和血小板衍生的生长因子诱导的平滑肌细胞（SMC）信号事件中起关键作用支持激活和调节SMC对血管损伤的反应。

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