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首页> 外文期刊>Archives of Toxicology >Effects of in utero meso-2,3-dimercaptosuccinic acid with calcium and ascorbic acid on lead-induced fetal development.
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Effects of in utero meso-2,3-dimercaptosuccinic acid with calcium and ascorbic acid on lead-induced fetal development.

机译：子宫中的meso-2,3-二巯基琥珀酸与钙和抗坏血酸对铅诱导的胎儿发育的影响。

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摘要

To examine the effects of meso-2,3-dimercaptosuccinic acid (DMSA) on developmental toxicity resulting from exposure to lead in utero, female albino mice were exposed to lead by drinking water contaminated with lead acetate for 4 weeks. After the cessation of lead exposure, female mice were supplemented by gavage with saline solution, DMSA, or DMSA and calcium as well as ascorbic acid from the fourth day of gestation until parturition, respectively. Lead levels (blood, liver, and bone) were measured at birth. Pups were then tested about neural development including surface righting reflex, cliff avoidance and air righting reflex. The markers of physical maturation, such as body weight, pinna unfolding, incisor eruption, and eye opening were also recorded. DMSA treatment decreased blood lead levels of pregnant mice, however, increased lead levels in both liver and bone of fetus, and delayed the early physical and neural development of offspring. Calcium and ascorbic acid reduced the transfer of lead to fetus. In conclusion, DMSA treatment during pregnancy enhances lead-induced fetal developmental toxicity.
机译：若要检查meso-2,3-二巯基琥珀酸（DMSA）对暴露于子宫内铅导致的发育毒性的影响，将雌性白化病小鼠暴露于铅中，该饮用水被乙酸铅污染了4周。停止铅暴露后，从妊娠第四天到分娩，分别给雌性小鼠补充食盐水，DMSA或DMSA以及钙以及抗坏血酸。在出生时测量铅水平（血液，肝脏和骨骼）。然后测试小学生的神经发育情况，包括表面扶正反射，避开悬崖和空气扶正反射。还记录了身体成熟的标志物，例如体重，耳廓展开，门牙萌出和睁眼。 DMSA处理可降低妊娠小鼠的血铅水平，但是会增加胎儿肝脏和骨骼中的铅水平，并延迟后代的早期身体和神经发育。钙和抗坏血酸减少了铅向胎儿的转移。总之，妊娠期DMSA治疗可增强铅诱导的胎儿发育毒性。

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