Listeria monocytogenes internalins bind to the human intestinal mucin MUC2.

Linden SK; Bierne H; Sabet C; Png CW; Florin TH; McGuckin MA; Cossart P

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Listeria monocytogenes internalins bind to the human intestinal mucin MUC2.

机译：单核细胞增生李斯特氏菌内毒素与人肠道粘蛋白MUC2结合。

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Listeria monocytogenes cross the intestinal barrier causing systemic infections with high mortality rates. Intestinal infection triggers release of intestinal mucus. We show that three L. monocytogenes internalins, InlB, InlC and InlJ all bound to MUC2 (the major component of intestinal mucus), but not to the cell surface mucin MUC1. Binding was strongest to InlB>InlC>InlJ (P < 0.001). Listerial internalins are characterized by their internalin domain, composed by leucine rich repeats (LRR) followed by an immunogloblin-like region. We report here that the internalin domain of the InlJ protein also bound MUC2, suggesting that an internalin domain is sufficient to bind to MUC2.

机译：单核细胞增生李斯特菌穿过肠道屏障，导致全身感染，死亡率高。肠道感染触发肠道粘液释放。我们显示三个单核细胞增生李斯特菌internalins，InlB，InlC和InlJ都与MUC2（肠道粘液的主要成分）结合，但不与细胞表面粘蛋白MUC1结合。与InlB> InlC> InlJ的结合最强（P <0.001）。李斯特菌内毒素的特征在于其内毒素结构域，该结构域由富含亮氨酸的重复序列（LRR）和免疫球蛋白样区域组成。我们在这里报告，InlJ蛋白的internalin结构域也结合了MUC2，这表明internalin结构域足以结合MUC2。

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来源
《Archives of microbiology》 |2008年第1期|共4页
作者
Linden SK; Bierne H; Sabet C; Png CW; Florin TH; McGuckin MA; Cossart P;
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正文语种 eng
中图分类医学微生物学（病原细菌学、病原微生物学）;植物学;
关键词
internalin; Mucins; Listeria monocytogenes; Mucous body substance; Human; 粘蛋白类; 利斯特氏菌; 单核细胞增生;

机译：internalin;Mucins;Listeria monocytogenes;Mucous body substance;Human;粘蛋白类;利斯特氏菌;单核细胞增生;

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专利

1. Listeria monocytogenes internalins bind to the human intestinal mucin MUC2. [J] . Linden SK, Bierne H, Sabet C, Archives of microbiology . 2008,第1期

机译：单核细胞增生李斯特氏菌内毒素与人肠道粘蛋白MUC2结合。
2. Select Listeria monocytogenes Subtypes Commonly Found in Foods Carry Distinct Nonsense Mutations in inlA, Leading to Expression of Truncated and Secreted Internalin A, and Are Associated with a Reduced Invasion Phenotype for Human Intestinal Epithelial Cells [J] . K. K. Nightingale, K. Windham, K. E. Martin, Applied and Environmental Microbiology . 2005,第12期

机译：在食物中常见的精选单核细胞增生李斯特菌亚型携带inlA中的明显无意义突变，导致截短和分泌的Internalin A表达，并与人类肠道上皮细胞的侵袭表型减少相关
3. Lactococcus lactis Expressing either Staphylococcus aureus Fibronectin-Binding Protein A or Listeria monocytogenes Internalin A Can Efficiently Internalize and Deliver DNA in Human Epithelial Cells [J] . Silvia Innocentin, Valeria Guimar?es, Anderson Miyoshi, Applied and Environmental Microbiology . 2009,第14期

机译：表达金黄色葡萄球菌纤连蛋白结合蛋白A或单核细胞增生李斯特菌Internalin A的乳酸乳球菌可以有效地内化和递送人上皮细胞中的DNA
4. Molecular subtyping of human and food-environmental Listeria monocytogenes isolates in northern Italy (2012) [C] . E. Amato, M. Tilola, N.M. Losio, International Conference on Environmental, Industrial and Applied Microbiology . 2014

机译：意大利北部的人和食品环境李米西亚单核细胞增生的分子亚细胞（2012年）
5. Molecular ecology of foodborne pathogens in primary production agriculture environments in northern Colorado and investigations in internalin A diversity in Listeria monocytogenes dup-1039c strains [D] . Manuel, Clyde Simmons 2011

机译：科罗拉多州北部主要生产农业环境中食源性病原体的分子生态学和单核细胞增生性李斯特菌dup-1039c菌株的Internalin A多样性调查
6. Select Listeria monocytogenes Subtypes Commonly Found in Foods Carry Distinct Nonsense Mutations in inlA Leading to Expression of Truncated and Secreted Internalin A and Are Associated with a Reduced Invasion Phenotype for Human Intestinal Epithelial Cells [O] . K. K. Nightingale, K. Windham, K. E. Martin, 2005

机译：食品中常见的选择单核细胞增生李斯特菌亚型携带inlA中的明显无义突变导致截短和分泌的Internalin A表达并与人类肠道上皮细胞的侵袭表型减少相关
7. Select Listeria monocytogenes Subtypes Commonly Found in Foods Carry Distinct Nonsense Mutations in inlA, Leading to Expression of Truncated and Secreted Internalin A, and Are Associated with a Reduced Invasion Phenotype for Human Intestinal Epithelial Cells [O] . Nightingale, K. K., Windham, K., Martin, K. E., 2005

机译：在食物中常见的选择单核细胞增生李斯特菌亚型携带inlA中的明显无意义突变，导致截短和分泌的Internalin A表达，并与人类肠道上皮细胞的侵袭表型减少相关

Listeria monocytogenes internalins bind to the human intestinal mucin MUC2.

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