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首页> 外文期刊>Archives of Toxicology >A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population.
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A genetic variant in miR-146a modifies colorectal cancer susceptibility in a Chinese population.

机译：miR-146a中的一种遗传变异可改变中国人大肠癌的易感性。

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摘要

MicroRNAs (miRNAs) are a family of endogenous, small, noncoding RNA molecules that involved in a wide range of biological processes including differentiation, proliferation, and apoptosis. A polymorphism G>C (rs2910164) is located in the stem region opposite to the mature miR-146a sequence. In our study, we investigated whether rs2910164 is associated with the risk of colorectal cancer (CRC) in a Chinese population. We genotyped the rs2910164 polymorphism using TaqMan method and evaluated the association with CRC risk in a case-control study, including 1,147 CRC patients and 1,203 cancer-free controls. Logistic regression models were used to assess the genetic effects on the development of CRC. Overall, we found that rs2910164 was significantly associated with the reduced CRC risk [GC/CC versus GG: adjusted odds ratio (OR)??.78, 95? confidence intervals (CIs)??.66-0.93]. In the stratification analysis, this decreased risk was also pronounced among non-smokers (0.75, 0.61-0.93), non-drinkers (0.77, 0.63-0.94), and no family history of cancer (0.79, 0.65-0.95). Furthermore, GC/CC genotypes were associated with reduced CRC susceptibility in intermediate differentiated CRC (0.75, 0.62-0.90), and similar effect was observed in patients with the advanced stage tumor (Dukes C and D) (0.76, 0.61-0.93). In conclusion, our results suggest that miR-146a rs2910164 may contribute to the susceptibility to CRC in a Chinese population. Further larger population-based prospective and functional studies are needed to validate our findings.
机译：微小RNA（miRNA）是一个内源性，小的，非编码性RNA分子家族，涉及广泛的生物过程，包括分化，增殖和凋亡。 G> C（rs2910164）多态性位于与成熟miR-146a序列相对的茎区域中。在我们的研究中，我们调查了rs2910164是否与中国人群大肠癌（CRC）的风险相关。我们使用TaqMan方法对rs2910164多态性进行基因分型，并在一项病例对照研究中评估了与CRC风险的相关性，其中包括1,147名CRC患者和1,203名无癌对照。使用逻辑回归模型评估遗传学对结直肠癌的影响。总的来说，我们发现rs2910164与降低的CRC风险显着相关[GC / CC与GG：调整比值比（OR）??。78，95？置信区间（CIs）≤.66-0.93]。在分层分析中，这种降低的风险在不吸烟者（0.75，0.61-0.93），不饮酒者（0.77，0.63-0.94）和没有癌症家族史（0.79，0.65-0.95）中也很明显。此外，GC / CC基因型与中分化CRC的CRC敏感性降低有关（0.75，0.62-0.90），晚期肿瘤患者（C和D病）的观察结果相似（0.76，0.61-0.93）。总之，我们的结果表明，miR-146a rs2910164可能有助于中国人群对CRC的易感性。需要进一步的基于人群的前瞻性和功能性研究来验证我们的发现。

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