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首页> 外文期刊>Archives of Toxicology >Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetylated derivatives in intestinal epithelial cells
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Toxicological interactions between the mycotoxins deoxynivalenol, nivalenol and their acetylated derivatives in intestinal epithelial cells

机译：霉菌毒素脱氧雪腐酚，雪腐酚及其乙酰化衍生物在肠上皮细胞中的毒理学相互作用

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In case of mycotoxin contaminations, food and feedstuff are usually contaminated by more than one toxin. However toxicological data concerning the effects of mycotoxin combinations are sparse. The intestinal epithelium is the first barrier against food contaminants and this constantly renewing organ is particularly sensitive to mycotoxins. The aim of this study was to investigate the effects of deoxynivalenol (DON) and four other type B trichothecenes (TCTB), 3-acetyldeoxynivalenol (3-ADON), 15-acetyldeoxynivalenol (15-ADON), nivalenol (NIV) and fusarenon-X (FX) alone or in combination on intestinal epithelial cells. Proliferating, non-transformed IPEC-1 cells were exposed to increasing doses of TCTB, alone or in binary mixtures and mycotoxin-induced cytotoxicity was measured with MTT test. The toxicological interactions were assessed using the isobologram-Combination index method. The five tested mycotoxins and their mixtures had a dose-dependent effect on the proliferating enterocytes. DON-NIV, DON-15-ADON and 15-ADON-3-ADON combinations were synergistic, with magnitude of synergy for 10 % cytotoxicity ranging from 2 to 7. The association between DON and 3-ADON also demonstrated a synergy but only at high doses, at lower doses antagonism was noted. Additivity was observed between NIV and FX, and antagonism between DON and FX. These results indicate that the simultaneous presence of mycotoxins in food commodities and diet may be more toxic than predicted from the mycotoxins alone. This synergy should be taken into account considering the frequent co-occurrence of TCTB in the diet.
机译：如果发生霉菌毒素污染，食物和饲料通常会被一种以上的毒素污染。然而，有关霉菌毒素组合影响的毒理学资料很少。肠上皮是抵抗食物污染物的第一道屏障，这个不断更新的器官对霉菌毒素特别敏感。这项研究的目的是调查脱氧雪腐烯醇（DON）和其他四种B型毛发纤毛虫（TCTB），3-乙酰基脱氧雪茄烯醇（3-ADON），15-乙酰基脱氧雪茄烯醇（15-ADON），nivalenol（NIV）和氟沙隆非X（FX）单独或组合在肠上皮细胞上。增殖的，未转化的IPEC-1细胞单独或以二元混合物形式接触不断增加的TCTB剂量，并通过MTT试验测量了霉菌毒素诱导的细胞毒性。毒理学相互作用使用等效线图结合指数法进行评估。五个测试的霉菌毒素及其混合物对增殖的肠上皮细胞具有剂量依赖性。 DON-NIV，DON-15-ADON和15-ADON-3-ADON组合具有协同作用，对10％细胞毒性的协同作用范围为2到7。DON和3-ADON之间的结合也显示出协同作用，但仅在在高剂量下，低剂量时有拮抗作用。在NIV和FX之间观察到可加性，在DON和FX之间观察到拮抗作用。这些结果表明，在食品和饮食中同时存在霉菌毒素可能比单独使用霉菌毒素所预测的毒性更大。考虑到饮食中TCTB的频繁共存，应考虑到这种协同作用。

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