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首页> 外文期刊>Archives of Toxicology >Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes.
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Elevated risk of hypertension induced by arsenic exposure in Taiwanese rural residents: possible effects of manganese superoxide dismutase (MnSOD) and 8-oxoguanine DNA glycosylase (OGG1) genes.

机译：台湾农村居民中砷暴露诱发的高血压风险升高：锰超氧化物歧化酶（MnSOD）和8-氧鸟嘌呤DNA糖基化酶（OGG1）基因的可能影响。

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摘要

Heavy metals, including arsenic and lead, may lead to cellular oxidative damage that is linked to hypertension. Manganese superoxide dismutase (MnSOD) is a scavenger of reactive oxygen species, and 8-oxoguanine DNA glycosylase (OGG1) is the major glycosylase that repairs DNA lesions. Interestingly, whether there is an elevated risk of hypertension with arsenic or lead exposure in individuals with genetic variations in MnSOD or OGG1 has not yet been investigated. Questionnaires were administered to 240 Taiwanese rural residents. Blood pressure and biochemical indicators were assessed in each subject. Urinary levels of arsenic and lead were measured with atomic absorption spectrometry; and MnSOD and OGG1 genotypes were identified via polymerase chain reaction. There was a dose-response relationship between urinary arsenic levels and risk of hypertension (P = 0.021, test for trend). However, there was no association between urinary lead levels and hypertension risk. Individuals with high urinary arsenic levels and the MnSOD Val-Ala/Ala-Ala genotypes had a greater risk of hypertension than those with low urinary arsenic levels and the MnSOD Val-Val genotype (odds ratio [OR] = 4.2, 95% confidence interval [CI] = 1.7-10.3). Subjects with a high urinary arsenic level and the OGG1 Cys-Cys genotype also had a greater risk of hypertension than those with a low urinary arsenic level and the OGG1 Ser-Ser/Ser-Cys genotypes (OR = 3.4, 95% CI = 1.1-10.7). Thus, both MnSOD and OGG1 genotypes may be prone to an increased risk of hypertension associated with arsenic exposure.
机译：重金属，包括砷和铅，可能导致与高血压有关的细胞氧化损伤。锰超氧化物歧化酶（MnSOD）是活性氧的清除剂，而8-氧鸟嘌呤DNA糖基化酶（OGG1）是修复DNA损伤的主要糖基化酶。有趣的是，尚未对具有MnSOD或OGG1基因变异的个体中砷或铅暴露引起高血压的风险增加进行研究。对240名台湾农村居民进行了问卷调查。在每个受试者中评估血压和生化指标。用原子吸收光谱法测定尿中的砷和铅含量;通过聚合酶链反应鉴定了MnSOD和OGG1基因型。尿砷水平与高血压风险之间存在剂量反应关系（P = 0.021，趋势检验）。但是，尿铅水平与高血压风险之间没有关联。尿砷水平高和MnSOD Val-Ala / Ala-Ala基因型的个体患高血压的风险比尿尿砷水平低和MnSOD Val-Val基因型低的个体（赔率[OR] = 4.2，95％置信区间[CI] = 1.7-10.3）。尿砷水平高和OGG1 Cys-Cys基因型的受试者也比低尿砷水平和OGG1 Ser-Ser / Ser-Cys基因型的受试者有更高的高血压风险（OR = 3.4，95％CI = 1.1 -10.7）。因此，MnSOD和OGG1基因型可能容易导致与砷暴露相关的高血压风险增加。

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