...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Toxicology >Bismuth overdosing-induced reversible nephropathy in rats.
【24h】

Bismuth overdosing-induced reversible nephropathy in rats.

机译：铋过量导致大鼠可逆性肾病。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Overdosing of colloidal bismuth subcitrate (CBS), used to treat peptic ulcers and Helicobacter pylori infections, has been reported to result in serious, though reversible, nephrotoxicity in humans. However, little is known about the nature of the renal damage induced by bismuth (Bi), and no well-described experimental model exists. Single large oral CBS doses (0.75, 1.5, and 3.0 mmol Bi/kg) were administered to three groups of 20 female Wistar rats. A control group (n = 20) received only the vehicle. Standard kidney function parameters, urinary excretion of N-acetyl-beta-D-glucosaminidase (NAG) and the Bi content were monitored in blood, urine, liver, and kidneys for 14 days. A dose of 3.0 mmol Bi/kg, 100 times the daily therapeutic dose, caused kidney damage within 6 h as detected by proteinuria, glucosuria, and elevated plasma urea and plasma creatinine levels. The kidneys of all animals, except two that died, recovered functionally within 10 days. At a dose of 1.5 mmol Bi/kg, clinical parameters changed less and normalized within 48 h, whereas a dose of 0.75 mmol Bi/kg induced no changes. Histological evaluation revealed that the S3 tubular segment necrotized first with additional necrotization of the S1/S2 segment when more Bi was absorbed. The lesions were accompanied by interstitial infiltrates of CD45+ leukocytes. In summary, we developed a rat model for Bi-induced reversible nephropathy. A large single oral overdose of CBS administered to Wistar rats led to damage to the proximal tubule, especially in the last segment.
机译：据报道，用于治疗消化性溃疡和幽门螺杆菌感染的胶体次柠檬酸铋（CBS）过量使用会对人类产生严重的（尽管可逆的）肾毒性。但是，对于由铋（Bi）引起的肾脏损害的性质知之甚少，并且不存在描述充分的实验模型。将大剂量口服CBS（0.75、1.5和3.0 mmol Bi / kg）给予三组，每组20只雌性Wistar大鼠。对照组（n = 20）仅接收车辆。监测14天的血液，尿液，肝脏和肾脏中的标准肾脏功能参数，尿液中N-乙酰基-β-D-氨基葡萄糖苷酶（NAG）的排泄量和Bi含量。 3.0 mmol Bi / kg的剂量（每日治疗剂量的100倍）在6小时内引起肾脏损害，这可通过蛋白尿，糖尿以及血浆尿素和肌酐水平升高来检测。除两只死亡的动物外，所有动物的肾脏都在10天内恢复了功能。在1.5 mmol Bi / kg的剂量下，临床参数变化较小，并在48小时内恢复正常，而0.75 mmol Bi / kg的剂量则无变化。组织学评估显示，当更多的Bi被吸收时，S3管状节段首先坏死，而S1 / S2节段又坏死。病变伴有CD45 +白细胞的间质浸润。总之，我们开发了一种Bi诱导的可逆性肾病的大鼠模型。向Wistar大鼠大剂量单次口服过量的CBS导致近端小管受损，尤其是在末段。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号