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首页> 外文期刊>Archives of Toxicology >Aluminium and lead toxicity revisited: mechanisms explaining the particular sensitivity of the brain to oxidative damage
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Aluminium and lead toxicity revisited: mechanisms explaining the particular sensitivity of the brain to oxidative damage

机译：铝和铅毒性再探：解释大脑对氧化损伤特别敏感的机制

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For several reasons the central nervous system is particularly sensitive to metal-induced oxidative stress (Verstrae-ten et al. 2008, this issue): the brain contains a high fraction of oxidizable polyunsaturated fatty acids, only relatively low activities of the antioxidant enzymes catalase, superox-ide dismutase and glutathione peroxidase, has a high oxygen consumption and a high iron content. Parkinson's disease is one of the neurodegenerative diseases where metal toxicity is suspected to play an important role (Verstraeten et al. 2008, this issue). This is based on the observation of high aluminium concentrations in post-mortem brains of patients with Parkinson's disease and on animal studies where administration of aluminium caused a strong decrease in the dopamine content of the striatum. Metals are not degraded and may accumulate to toxic levels. This and the diversity of not yet fully understood mechanisms is the reason why metal toxicity is one of the hot topics of our journal (Hengstler etal. 2003; Barbosa etal. 2006a, b; Brulport et al. 2007; Devi et al. 2007; Hengstler and Bolt 2007; Kobayashi et al. 2007; M'Bemba-Meka et al. 2007; Montes et al. 2007; Nampoothiri et al. 2007; Periyakarup-pan etal. 2007; Posser etal. 2007; Santos etal. 2007; Beyersmann and Hartwig 2008; Glahn et al. 2008)#
机译：由于多种原因，中枢神经系统对金属诱导的氧化应激特别敏感（Verstrae-ten等，2008，此问题）：大脑含有高比例的可氧化多不饱和脂肪酸，而抗氧化酶过氧化氢酶的活性相对较低，超氧化物歧化酶和谷胱甘肽过氧化物酶，具有高耗氧量和高铁含量。帕金森氏病是其中金属毒性被认为起重要作用的神经退行性疾病之一（Verstraeten等，2008，此问题）。这是基于对帕金森氏病患者的验尸大脑中高铝含量的观察，以及基于动物研究，其中铝的施用导致纹状体中多巴胺含量大大降低。金属不会降解，并可能积累到有毒水平。这种和尚未完全理解的机制的多样性是为什么金属毒性成为我们期刊的热门话题之一的原因（Hengstler等，2003; Barbosa等，2006a，b; Brulport等，2007; Devi等，2007; H。 Hengstler and Bolt 2007; Kobayashi等2007; M'Bemba-Meka等2007; Montes等2007; Nampoothiri等2007; Periyakarup-pan等2007; Posser等2007; Santos等2007; Beyersmann and Hartwig 2008; Glahn et al.2008）＃

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