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首页> 外文期刊>Archives of Toxicology >Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs)
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Predicting pulmonary fibrosis in humans after exposure to multi-walled carbon nanotubes (MWCNTs)

机译：预测多壁碳纳米管（MWCNT）暴露后人的肺纤维化

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The increased production and use of multi-walled carbon nanotubes (MWCNTs) in a diverse array of consumer, medical, and industrial applications have raised concerns about potential human exposure to these materials in the workplace and ambient environments. Inhalation is a primary route of exposure to MWCNTs, and the existing data indicate that they are potentially hazardous to human health. While a 90-day rodent inhalation test (e.g., OECD Test No. 413: subchronic inhalation toxicity: 90-day study or EPA Health Effects Test Guidelines OPPTS 870.3465 90-day inhalation toxicity) is recommended by the U.S. Environmental Protection Agency Office of Pollution Prevention and Toxics for MWCNTs (and other CNTs) if they are to be commercially produced (Godwin et al. in ACS Nano 9:3409-3417, 2015), this test is time and cost-intensive and subject to scientific and ethical concerns. As a result, there has been much interest in transitioning away from studies on animals and moving toward human-based in vitro and in silico models. However, given the multiple mechanisms of toxicity associated with subchronic exposure to inhaled MWCNTs, a battery of non-animal tests will likely be needed to evaluate the key endpoints assessed by the 90-day rodent study. Pulmonary fibrosis is an important adverse outcome related to inhalation exposure to MWCNTs and one that the non-animal approach should be able to assess. This review summarizes the state-of-the-science regarding in vivo and in vitro toxicological methods for predicting MWCNT-induced pulmonary fibrosis.
机译：在各种消费，医疗和工业应用中，越来越多的多壁碳纳米管（MWCNT）的生产和使用引起了人们对在工作场所和周围环境中暴露于这些材料的潜在担忧。吸入是接触多壁碳纳米管的主要途径，现有数据表明它们对人体健康具有潜在危害。美国环境保护局污染办公室建议进行90天的啮齿动物吸入测试（例如，经合组织测试编号413：亚慢性吸入毒性：90天研究或EPA健康影响测试指南OPPTS 870.3465 90天吸入毒性）如果要商业生产多壁碳纳米管（和其他碳纳米管），请参见《预防和毒理学》（Godwin等人在ACS Nano 9：3409-3417，2015），该测试既费时又费钱，并且受到科学和道德方面的关注。结果，从动物研究转向以人为基础的体外和计算机模拟模型引起了人们的极大兴趣。但是，考虑到与吸入MWCNT亚慢性暴露相关的多种毒性机制，可能需要进行一系列非动物试验来评估90天啮齿类动物研究评估的关键终点。肺纤维化是与吸入多壁碳纳米管有关的重要不良后果，非动物方法应能够评估这一结果。这篇综述总结了有关预测MWCNT诱导的肺纤维化的体内和体外毒理学方法的最新技术。

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