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首页> 外文期刊>ASAIO journal >First in Man: Sternal Reconstruction with Autologous Stem Cells
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First in Man: Sternal Reconstruction with Autologous Stem Cells

机译：人为先：自体干细胞的胸骨重建

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Sternal nonunion is associated with high morbidity and treated using rigid plate and screw fixation. This is the first reported example of successful sternal reconstruction using adipose-derived stromal vascular fraction (SVF) stem cells in addition to traditional techniques. Mesenchymal stem cells, one component of the SVF, play an important role in bone healing and were therefore used to promote remedial processes in a patient with sternal nonunion. A 3D printed model of the patient's sternum was used for preoperative planning of the plating. Intraoperatively, SVF was isolated using ultrasonic cavitation and previously planned sternal plating was completed. A total of 300 million cells were delivered via both local injection and intravenously before chest closure. The patient's pain dramatically decreased, commensurate with healed areas of nonunion by 3 months and maintained at 6 months postoperatively, supported by three-dimensional computed tomography imaging. Utilizing autologous stem cells from the SVF in conjunction with existing plating techniques may provide an optimal platform to stabilize the sternum and promote bone healing, although additional study is recommended.
机译：胸骨骨不连与高发病率有关，并采用刚性钢板和螺钉固定治疗。这是除传统技术外，还使用脂肪来源的基质血管部分（SVF）干细胞成功完成胸骨重建的第一个报道的例子。间充质干细胞是SVF的一种成分，在骨愈合中起着重要作用，因此被用于促进胸骨骨不连患者的修复过程。患者胸骨的3D打印模型用于电镀前的计划。术中，使用超声空化分离SVF，并完成了先前计划的胸骨板。在胸腔闭合之前，通过局部注射和静脉内递送总共3亿个细胞。在三维计算机断层扫描成像的支持下，患者的疼痛显着减轻，与不愈合的愈合区域相对应，缩短了3个月，并在术后6个月得以维持。 SVF的自体干细胞与现有的铺板技术结合使用可能会提供一个稳定胸骨和促进骨愈合的最佳平台，尽管建议进行其他研究。

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