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首页> 外文期刊>Arthritis and Rheumatism >Whole stimulated salivary flow: correlation with the pathology of inflammation and damage in minor salivary gland biopsy specimens from patients with primary Sjogren's syndrome but not patients with sicca.
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Whole stimulated salivary flow: correlation with the pathology of inflammation and damage in minor salivary gland biopsy specimens from patients with primary Sjogren's syndrome but not patients with sicca.

机译：整个刺激的唾液流动：与患有原发性干燥综合征的患者（未见干燥性干燥患者）的小唾液腺活检标本的炎症和损害的病理学相关。

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OBJECTIVE: To determine which measure of the salivary flow rate, stimulated or unstimulated, is most strongly associated with pathologic changes in minor salivary gland (MSG) biopsy specimens, and to explore the correlation of salivary flow with oral surface damage, disease duration, and symptom severity in patients with primary Sjogren's syndrome (SS). METHODS: In all patients (n = 32), a biopsy of the MSG was performed, and stimulated salivary flow was assessed. Beginning in 2002, unstimulated salivary flow was also assessed. Scores for the severity of symptoms, according to the decayed/missing/filled teeth (DMF) index, were recorded. Associations between measures of salivary flow and covariates characterizing pathology were examined. RESULTS: A definite association between stimulated salivary flow and the MSG focus score, the grade of MSG fibrosis, the duration of dry mouth symptoms, and the DMF score was observed. In contrast, unstimulated salivary flow was not associated with fibrosis, atrophy, the DMF score, or the duration of dry mouth symptoms. In patients with primary SS, the DMF score was associated with pathologic changes in the MSG. Among patients with sicca, 57.9% had an abnormal unstimulated salivary flow rate (versus 82.4% of patients with primary SS), and 15.2% had an abnormal stimulated salivary flow rate (versus 61.8% of patients with primary SS). Among patients with sicca, neither stimulated salivary flow nor unstimulated salivary flow was associated with the degree of fibrosis or atrophy or with the DMF score. CONCLUSION: Compared with unstimulated salivary flow, stimulated salivary flow appeared to be a better measure of inflammation (according to the focus score) and fibrosis. In patients with sicca, the unstimulated salivary flow rate appeared to be abnormal more commonly compared with the stimulated salivary flow rate. In the future, stimulated salivary flow may serve as a noninvasive surrogate biomarker of inflammation and fibrosis as well as a measure of response to treatment in patients with primary SS.
机译：目的：确定哪种唾液流速（刺激或未刺激）与未成年人唾液腺（MSG）活检标本的病理变化最密切相关，并探讨唾液流速与口腔表面损伤，疾病持续时间和原发性干燥综合征（SS）患者的症状严重程度。方法：对所有患者（n = 32）进行了MSG活检，并评估了唾液刺激流。从2002年开始，还评估了未刺激的唾液流量。记录根据蛀牙/缺失/缺牙（DMF）指数得出的症状严重程度评分。唾液流量的量度和表征病理的协变量之间的关联进行了检查。结果：观察到唾液刺激流量与味精聚焦评分，味精纤维化程度，口干症状持续时间和DMF评分之间存在明确的关联。相反，唾液流动不受刺激与纤维化，萎缩，DMF评分或口干症状持续时间无关。在原发性SS患者中，DMF评分与MSG的病理变化有关。干燥期患者中，未刺激的唾液流量异常率为57.9％（原发性SS患者为82.4％），受刺激的唾液流速异常为15.2％（原发性SS患者为61.8％）。在干燥期患者中，唾液流量增加或唾液流量未刺激均与纤维化或萎缩程度或DMF评分无关。结论：与未刺激的唾液流相比，刺激的唾液流似乎是炎症（根据病灶评分）和纤维化的更好指标。干燥期患者中，未刺激的唾液流速似乎比刺激的唾液流速异常。将来，刺激的唾液流动可能会成为炎症和纤维化的非侵入性替代生物标志物，以及对原发性SS患者治疗反应的衡量指标。

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