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首页> 外文期刊>Arthritis care & research >Effects of infertility, pregnancy loss, and patient concerns on family size of women with rheumatoid arthritis and systemic lupus erythematosus.
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Effects of infertility, pregnancy loss, and patient concerns on family size of women with rheumatoid arthritis and systemic lupus erythematosus.

机译：不孕症，妊娠减少和患者的担忧对类风湿关节炎和系统性红斑狼疮妇女的家庭规模的影响。

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Women with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) have fewer children on average than other women. We sought to determine the roles of infertility, pregnancy loss, and personal choice on family size in women with these diseases.A reproductive history questionnaire was completed by women with RA and SLE participating in a longitudinal observational study. Within each disease cohort, participants were divided into 3 groups: those interested in having children at symptom onset who had either fewer children than planned (group A) or the same number as planned (group B), and those no longer interested in having children at diagnosis (group C).Of the 578 RA and 114 SLE women surveyed, >60% were in group C. Of those interested in having children, 55% with RA and 64% with SLE had fewer children than originally planned. Among women with RA, group A had 1 less pregnancy, 1 less live birth, and an infertility rate 1.5 times higher than group B; the miscarriage rate was similar in both groups. Compared to SLE group B, SLE group A had a similar number of pregnancies, but a 3-fold higher rate of miscarriage and 1 less live birth. Concerns about child health and personal welfare were associated with a lower pregnancy rate.In this population, more than one-half of young women with RA or SLE had fewer biologic children than desired. While patient choice plays a role, infertility in RA patients and miscarriage in SLE patients are also important.
机译：类风湿关节炎（RA）和系统性红斑狼疮（SLE）的妇女平均比其他妇女少生育。我们试图确定不育，妊娠流产和个人选择对这些疾病女性家庭规模的影响。生殖史问卷由RA和SLE女性参与纵向观察研究完成。在每个疾病队列中，参与者分为3组：对有症状发作的孩子感兴趣的孩子，其孩子数少于计划数（A组）或与计划的数目相同（B组），以及不再对生孩子感兴趣在接受调查的578名RA和114名SLE妇女中，> 60％属于C组。在那些有孩子的人中，RA的55％和SLE的64％的孩子比最初计划的要少。在患有RA的女性中，A组的妊娠减少1例，活产减少1例，不育率比B组高1.5倍;两组的流产率相似。与SLE组B相比，SLE A组的怀孕次数相似，但流产率高3倍，活产少1例。对儿童健康和个人福利的担忧与较低的怀孕率有关。在这一人群中，超过一半的患有RA或SLE的年轻女性的生物学子女少于预期。尽管患者的选择起着重要作用，但RA患者的不孕症和SLE患者的流产也很重要。

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