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首页> 外文期刊>Asian Journal of Chemistry: An International Quarterly Research Journal of Chemistry >Pharmacokinetics and Relative Bioavailability of Breviscapine Pills in Human Plasma by HPLC
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Pharmacokinetics and Relative Bioavailability of Breviscapine Pills in Human Plasma by HPLC

机译：高效液相色谱法测定灯盏花素丸在人血浆中的药代动力学和相对生物利用度

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摘要

To evaluate the bioequivalence of scutellarin in breviscapine pills and tablets, the randomized two-way crossover study was conducted in 18 healthy volunteers. After a single dose (containing 160 mg brevisapine), the plasma drug levels were determined by HPLC. By analysis of variance, the main pharmacokinetics parameters of test and reference formulations were followed that t_(max) were 5.94 ±0.24 and 6.00 ± 0.0 (h), C_(max) were 645.23 ± 48.71 and 599.88 ±61.19 (ng/mL), t_(1/2) were 3.68 ± 2.15 and 4.05 ± 2.74 (h), AUC_(0-→ 24) were 3726.69 ± 700.06 and 3213.94 ± 667.88 (ng/mL·h). The results showed that the two formulations were bioequivalent. The relative bioavailability of the Breviscapin pills was within 117.89 ± 19.16 %.
机译：为了评价灯盏花素在灯盏花素丸和片剂中的生物等效性，在18位健康志愿者中进行了随机双向交叉研究。单次服用（含160 mg布雷维沙平）后，通过HPLC测定血浆药物水平。通过方差分析，遵循测试和参考制剂的主要药代动力学参数，t_（max）为5.94±0.24和6.00±0.0（h），C_（max）为645.23±48.71和599.88±61.19（ng / mL） ，t_（1/2）为3.68±2.15和4.05±2.74（h），AUC_（0-→24）为3726.69±700.06和3213.94±667.88（ng / mL·h）。结果表明两种制剂是生物等效的。灯盏花素丸的相对生物利用度在117.89±19.16％之内。

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