Synthesis of N'-(Substituted benzylidene)-1-benzofuran-2-earbohydrazide and 5-(5-Substituted-1-benzofuran-2-yl)-1,3,4-oxadiazole-2-thiol as Potent Antioxidants

CHANDRASHEKAR JAVALI; M.D.KARVEKARI

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Synthesis of N'-(Substituted benzylidene)-1-benzofuran-2-earbohydrazide and 5-(5-Substituted-1-benzofuran-2-yl)-1,3,4-oxadiazole-2-thiol as Potent Antioxidants

机译：N'-（取代的亚苄基）-1-苯并呋喃-2-乙酰肼和5-（5-取代的-1-苯并呋喃-2-基）-1,3,4-恶二唑-2-硫醇的合成作为有效的抗氧化剂

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The reactions of substituted benzofuran-2-carbohydrazide(1)with various aromatic substituted aldehydes and carbon disulphide yielded corresponding N'-(substituted benzyl-idene)-1-benzofuran-2-carbohydrazide(2a-f)and with carbon disulphide yielded 5-(5-substituted-1-benzofuran-2-yl)-1,3,4-oxadiazole-2-thiols(3a-c),respectively.These compounds were characterized by IR,~1H NMR and mass spectra.All the compounds were screened for their in vitro antioxidant activity using DPPH method and antimicrobial activity by cup-plate diffusion method.The compounds 2c,3a and 3b shown potent radical scavenging activity and 2a,2d,3b and 3c have shown moderate antimicrobial activity.

机译：取代的苯并呋喃-2-碳酰肼（1）与各种芳族取代醛和二硫化碳的反应生成相应的N'-（取代的苄叉基）-1-苯并呋喃-2-碳酰肼（2a-f）和二硫化碳-（5-取代的1-苯并呋喃-2-基）-1,3,4-恶二唑-2-硫醇（3a-c），分别经IR，〜1H NMR和质谱表征。用DPPH法筛选化合物的体外抗氧化活性，并通过杯板扩散法筛选其抗菌活性。化合物2c，3a和3b显示出有效的自由基清除活性，而2a，2d，3b和3c显示出中等的抗菌活性。

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《Asian Journal of Chemistry: An International Quarterly Research Journal of Chemistry》 |2008年第6期|共5页
作者
CHANDRASHEKAR JAVALI; M.D.KARVEKARI;
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正文语种 eng
中图分类化学;
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Synthesis; Substituted benzofuran benzyl-idine; Benzofuran oxadiazole thiol; Diphenyl picrylhydryzyl; Antimicrobial and Antioxidant activity.;

机译：合成;取代的苯并呋喃苄基吡啶;苯并呋喃恶二唑硫醇;二苯基吡啶羟基;抗菌和抗氧化活性。;

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Synthesis of N'-(Substituted benzylidene)-1-benzofuran-2-earbohydrazide and 5-(5-Substituted-1-benzofuran-2-yl)-1,3,4-oxadiazole-2-thiol as Potent Antioxidants

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