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首页> 外文期刊>Asian Journal of Chemistry: An International Quarterly Research Journal of Chemistry >A New Modified Reverse Phase High Performance Liquid Chromatography Method for Estimation and Validation of Paracetamol and Diclofenac Sodium in Combined Dosage Pharmaceutical Formulation
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A New Modified Reverse Phase High Performance Liquid Chromatography Method for Estimation and Validation of Paracetamol and Diclofenac Sodium in Combined Dosage Pharmaceutical Formulation

机译：一种新的改进的反相高效液相色谱法，用于联合剂量药物制剂中对乙酰氨基酚和双氯芬酸钠的估计和验证

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摘要

A new modified simple,selective,rapid,precise and economical reversed phase high performance liquid chromatography(RP-HPLC)method has been developed and validated for the simultaneous estimation of paracetamol and diclofenac sodium from solid oral dosage form.This combination is used as an analgesic and antipyretic disorders.The method was carried out on a LIChroCART~R RP-18(125 mm X i.d-4 mm,pore-5 mu m)column with a mobile phase consisting of rnethanol:sodium acetate buffer(0.808 % solution of anhydrous sodium acetate in water,pH:8.0)in the ratio 70:30(v/v).The flow rate was 0.5 mL/min and the effluent was monitored for paracetamol at 257 nm and for diclofenac sodium at 254 nm(Waters 2487 dual absorbance detector).The validation of the proposed method was also carried out in terms of linearity,accuracy,precision,symmetry factor,plate count,regression and recovery.The retention time of paracetamol and diclofenac sodium was 2.12 and 4.08 min,respectively.Due to its simplicity,accuracy and economic value,the proposed method can be used for routine quality control analysis of these drugs in combined dosage form.
机译：已开发出一种经过改进的简单，选择性，快速，精确，经济的反相高效液相色谱（RP-HPLC）方法，并已验证了该方法可同时从固体口服剂型中估算对乙酰氨基酚和双氯芬酸钠。该方法在LIChroCART〜R RP-18（125 mm X id-4 mm，孔径5μm）色谱柱上进行，流动相由甲醇：乙酸钠缓冲液（0.808％以70:30（v / v）的比率在水中的无水乙酸钠（pH：8.0）。流速为0.5 mL / min，并监测257 nm处的扑热息痛和254 nm处的双氯芬酸钠的流出物（Waters 2487）线性，准确度，精密度，对称性因子，塔板数，回归和回收率等方法也对该方法进行了验证。扑热息痛和双氯芬酸钠的保留时间分别为2.12和4.08 min。由于其简单性，准确性既经济又经济，该方法可用于这些剂型的常规质量控制分析。

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