...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Artificial cells, blood substitutes, and biotechnology >Extracorporeal whole blood immuno-adsorption of passively transferred myasthenia gravis rabbits by cellulose-tryptophan column
【24h】

Extracorporeal whole blood immuno-adsorption of passively transferred myasthenia gravis rabbits by cellulose-tryptophan column

机译：纤维素色氨酸柱对被动转移性重症肌无力兔的体外全血免疫吸附

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The whole blood immuno-adsorption (WBIA) system, using an adsorbent to remove pathogenic antibodies of Myasthenia Gravis (MG), was studied. Cellulose-tryptophan adsorbent was synthesized and purified in our lab. Experimental autoimmune myasthenia gravis (EAMG) rabbits were passively transferred with immunoglobulin from patients with myasthenia gravis. The rabbits underwent extracorporeal whole blood adsorption for 2 hours. Results showed no significant damage to blood cells and no changes in the concentrations of electrolytes. Total protein decreased by 12.6% (P0.05) and globulin protein decreased 21.9% (P0.05). The overall removal of antibodies against nicotinic acetylcholine receptor (nAChR) was 49.85%. The percentage of decrement of compound muscle action potential in 3, 5, 10Hz of EAMG rabbits all dropped down after the treatment. The quantity of neuromuscular junctions per unit area (25 mm2) increased significantly after treatment (P0.05). In conclusion, the adsorbent was biocompatible, safe for whole blood immuno-adsorption. Whole blood immuno-adsorption improved clinical manifestation and neuromuscular function of the passively transferred EAMG rabbits.
机译：研究了使用吸附剂去除重症肌无力（MG）的致病性抗体的全血免疫吸附（WBIA）系统。在我们的实验室中合成并纯化了纤维素色氨酸吸附剂。重症肌无力患者的免疫球蛋白被动转移实验性自身免疫性重症肌无力（EAMG）兔。兔子进行体外全血吸附2小时。结果显示对血细胞无明显损害，电解质浓度无变化。总蛋白下降了12.6％（P <0.05），球蛋白下降了21.9％（P <0.05）。抗烟碱样乙酰胆碱受体（nAChR）抗体的总去除率为49.85％。治疗后，在3、5、10Hz的EAMG兔中，复合肌肉动作电位的下降百分比均下降。治疗后每单位面积（25 mm2）的神经肌肉接头数量显着增加（P <0.05）。总之，该吸附剂具有生物相容性，对全血免疫吸附安全。全血免疫吸附改善了被动转移EAMG兔的临床表现和神经肌肉功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号