Early spatiotemporal progress of myelinated nerve fiber regenerating through biological chitin conduit after injury

ZhangC.; ZhangP.; WangY.; YuK.; KouY.; JiangB.

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Early spatiotemporal progress of myelinated nerve fiber regenerating through biological chitin conduit after injury

机译：损伤后通过生物几丁质导管再生有髓神经纤维的时空进展

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Chitin conduits to bridge nerve injuries with a small gap (2mm) give us a biological window in which the peripheral nerve regeneration process can be observed. In this study, the regeneration process was observed on different intervals postoperatively. Histological analysis revealed that the early regeneration process occurred in three phase: degeneration and matrix phase, axonal and Schwann migration phase, myelination and maturation phase. Schwann cells grew into the lumen from both the proximal and distal nerve segments. Axonal regrowth progressed at an average rate of 1.4 mm/d. Regenerating axonal fibers were myelinated by Schwann cells from both sides of the conduit.

机译：几丁质导管以较小的间隙（2毫米）桥接神经损伤，为我们提供了一个可以观察到周围神经再生过程的生物学窗口。在这项研究中，术后不同时间观察到再生过程。组织学分析表明，早期再生过程发生在三个阶段：变性和基质阶段，轴突和雪旺氏迁移阶段，髓鞘形成和成熟阶段。雪旺氏细胞从近端和远端神经节段进入管腔。轴突再生长以1.4mm / d的平均速率进行。雪旺细胞从导管的两侧使轴突纤维再生。

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《Artificial cells, blood substitutes, and biotechnology》 |2010年第2期|共6页
作者
ZhangC.; ZhangP.; WangY.; YuK.; KouY.; JiangB.;
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正文语种 eng
中图分类生物医学工程;
关键词
Axon; Conduit; Peripheral nerve regeneration; Rats; Schwann cell;

机译：轴突;导管;周围神经再生;大鼠;Schwann细胞;

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1. Early spatiotemporal progress of myelinated nerve fiber regenerating through biological chitin conduit after injury [J] . ZhangC., ZhangP., WangY., Artificial cells, blood substitutes, and biotechnology . 2010,第2期

机译：损伤后通过生物几丁质导管再生有髓神经纤维的时空进展
2. Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit [J] . Pei-xun Zhang, A Li-ya, Yu-hui Kou Ph.D., Neural regeneration research . 2015,第1期

机译：周围神经损伤的生物导管小间隙套筒桥接方法：导管中神经纤维的再生规律
3. Biological conduit small gap sleeve bridging method for peripheral nerve injury：regeneration law of nerve ifbers in the conduit [J] . Pei-xun Zhang, Li-ya A, Yu-hui Kou, 中国神经再生研究（英文版） . 2015,第001期

机译：生物导管小间隙套管桥接方法治疗周围神经损伤：导管中神经纤维的再生规律
4. Double Layer Nerve Conduit for Peripheral Nerve Regeneration Using Grooved Conductive Fibers [C] . Xinyue Lu, Jing Liang, Rahim Jindani, Society for Biomaterials annual meeting and exposition . 2014

机译：双层神经导管，用于使用沟槽和导电纤维进行周围神经再生
5. Incorporation of guidance cues in novel nerve guidance conduits for peripheral nerve regeneration of large defects. [D] . Shah, Munish B. 2016

机译：在新的神经引导导管中引入引导线索，以使大缺陷的周围神经再生。
6. Abstract 192: Silk Fibroin Based Conduits Filled With Native Spider Silk Fibers Successfully Promoted Nerve Regeneration In A 10 Mm Sciatic Nerve Defect In Rats [O] . Lorenz Semmler, Eva Györy, Sonja Wolf, 2020

机译：摘要192：基于丝绸肌素的导管填充了天然蜘蛛丝纤维在大鼠10毫米坐骨神经缺陷中成功促进了神经再生
7. Biological conduit small gap sleeve bridging method for peripheral nerve injury: regeneration law of nerve fibers in the conduit [O] . Pei-xun Zhang, A Li-ya, Yu-hui Kou, 2015

机译：生物导管小间隙套管治疗周围神经损伤的方法：导管中神经纤维的再生规律
8. Use of GDNF Releasing Nanofiber Nerve Guide Conduits for the Repair of Conus Medullaris/Cauda Equina Injury in the Nonhuman Primate. [R] . Havton, L., Christe, K. 2015

机译：使用GDNF释放纳米纤维神经导管修复非人类灵长类动物的圆锥/尾状核损伤。

Early spatiotemporal progress of myelinated nerve fiber regenerating through biological chitin conduit after injury

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