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首页> 外文期刊>Artificial cells, blood substitutes, and biotechnology >Biocompatibility of acellular nerves of different mammalian species for nerve tissue engineering
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Biocompatibility of acellular nerves of different mammalian species for nerve tissue engineering

机译：不同哺乳动物物种的脱细胞神经在神经组织工程中的生物相容性

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摘要

To explore the biocompatibility of acellular nerves of different mammalian species, for the acellular nerves derived from rats and rabbits, the morphology, immunocompatibility, and cytocompatibility with bone marrow stromal cells (BMSCs) were evaluated. The results indicated that the tridimensional architecture and main proteins of endoneurial tubes in both biomaterials were well retained. The nerve scaffolds did not show immunogenicity or cytotoxicity, but facilitated growth of BMSCs and secretion of neurotrophic factors in vitro. In conclusion, acellular nerves of different species possess favorable biocompatibility, and xenogenic acellular nerves combined with BMSCs have potential to replace allografts for peripheral nerve reconstruction.
机译：为了探索不同哺乳动物物种的脱细胞神经的生物相容性，对于源自大鼠和兔子的脱细胞神经，评估了其形态，免疫相容性以及与骨髓基质细胞（BMSCs）的细胞相容性。结果表明，两种生物材料中的神经内膜管的三维结构和主要蛋白质都得到了很好的保留。神经支架没有显示免疫原性或细胞毒性，但在体外促进了BMSC的生长和神经营养因子的分泌。总之，不同物种的脱细胞神经具有良好的生物相容性，异种脱细胞神经与BMSC结合具有替代同种异体移植物重建周围神经的潜力。

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