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首页> 外文期刊>Artificial Organs >The stairway: a novel behavioral test detecting sensomotoric stroke deficits in rats.
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The stairway: a novel behavioral test detecting sensomotoric stroke deficits in rats.

机译：楼梯：一种新的行为测试，可检测大鼠的感觉运动性脑卒中。

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摘要

New therapeutic concepts of cell and tissue replacement therapies have been introduced in treatment of neurological disorders which require robust and sensitive sensomotoric behavioral diagnostic test systems for experimental research. However, most test arrays available are either expensive and/or sensitive to environmental disturbances. Moreover, an extensive training phase for experimental animals is often required by conventional tests to get reproducible data. In this study, we describe a new test array, the Stairway, that is robust, cost-effective, and needs only a minimum training phase. Its efficiency is evaluated in comparison to the well-established RotaRod and modified neurological severity score. Stroke was induced by middle cerebral artery occlusion. Human umbilical cord blood transplantation (n = 18) was performed 24 h after stroke by intravenous injection of suspended cells in comparison to control injections (n = 18), while behavioral assessment was carried out continuously for 29 days.Furthermore, development of lesions was monitored by magnetic resonance imaging. The results reveal the Stairway test as a simple, highly reproducible, and easy manageable test system thus reflecting therapeutic benefits precisely.
机译：细胞和组织替代疗法的新治疗概念已被引入神经系统疾病的治疗中，而神经系统疾病需要强大而灵敏的感觉运动行为诊断测试系统进行实验研究。但是，大多数可用的测试阵列价格昂贵和/或对环境干扰敏感。此外，常规测试通常需要对实验动物进行广泛的训练，以获取可重现的数据。在这项研究中，我们描述了一种新的测试阵列Stairway，该阵列坚固耐用，具有成本效益，并且只需要最少的培训阶段。与公认的RotaRod和改良的神经系统严重程度评分相比，可评估其效率。脑中动脉闭塞诱发中风。与对照组相比（n = 18），中风后24小时通过静脉注射悬浮细胞进行人脐带血移植（n = 18），而行为评估连续进行了29天。通过磁共振成像监测。结果表明Stairway测试是一种简单，高度可重复且易于管理的测试系统，从而准确反映出治疗的益处。

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