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Future of regenerative medicine: challenges and hurdles.

机译:再生医学的未来:挑战和障碍。

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摘要

Tissue regeneration strategies such as tissue engineering, growth factor administration, and stem cell-based therapies have undergone significant development over the past two decades. Most notably, we are much closer to realizing the engineering of whole organs and tissue with complex architecture than we were 5 years ago. A major driving force has been the demand placed by the scientific community at large and the public to go beyond simple engineering of tissues and demonstrate functionality in engineered tissues and functional recovery upon transplantation. Some recent advances include de novo engineering of bone, engineering of fully functional bladder, and vascularization of skeletal muscle constructs. Notwithstanding, several challenges lie ahead in making regenerative medicine a viable science of the future, the key being the evolution of programs and policies that promote a close relationship among government agencies, private sector, and academia, more specifically between materials scientists, biologists, and clinicians.
机译:在过去的二十年中,组织再生策略(例如组织工程,生长因子管理和基于干细胞的疗法)经历了重大发展。最值得注意的是,与5年前相比,我们更接近实现具有复杂体系结构的整个器官和组织的工程设计。一个主要的推动力是整个科学界和公众提出的要求,不仅限于简单的组织工程,而且还证明了工程组织的功能以及移植后的功能恢复。最近的一些进展包括骨骼的从头工程,膀胱全功能工程以及骨骼肌结构的血管形成。尽管如此,使再生医学成为未来可行的科学仍面临着一些挑战,关键在于计划和政策的发展,这些政策和政策促进了政府机构,私营部门和学术界之间,尤其是材料科学家,生物学家和科学家之间的密切关系。临床医生。

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