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首页> 外文期刊>Artificial Organs >Efficacy Comparison Between Simple Mixed-Dilution and Simple Mid-Dilution On-Line Hemodiafiltration Techniques: A Crossover Study
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Efficacy Comparison Between Simple Mixed-Dilution and Simple Mid-Dilution On-Line Hemodiafiltration Techniques: A Crossover Study

机译：简单混合稀释和简单中间稀释在线血液透析滤过技术的功效比较：交叉研究

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摘要

Mid-dilution and mixed-dilution on-line hemodiafiltration (OL-HDF) techniques are innovated to overcome the limitations of two standard techniques including predilution and postdilution. Unfortunately, the head-to-head comparisons between these two novel techniques in the same study are still limited. Moreover, the original mid-dilution and mixed-dilution OL-HDF need special dialyzers and special machines. In the present study, simple mid-dilution and simple mixed-dilution OL-HDF were settled with the aim for clinical use in general hemodialysis (HD) centers. The efficacies of uremic toxins removal between both modalities were measured and compared. This prospective randomized crossover study was conducted on 12 stable HD patients undergoing simple mixed-dilution and simple mid-dilution OL-HDF techniques. HD prescriptions were similar in both techniques. The dialysis efficacies were determined by calculating small- (urea, creatinine, and phosphate) and middle-molecule (beta-2 microglobulin [β2M]) removal. Moreover, potential complications such as high transmembrane pressure (TMP) and protein loss were also observed. Simple mixed-dilution OL-HDF provided significantly greater clearances of urea, creatinine, and β2M when compared with the simple mid-dilution OL-HDF techniques. Phosphate clearances in both techniques were comparable. In addition, TMP and dialysate albumin loss were not different. There were no intradialytic complications in both techniques. Simple mixed-dilution OL-HDF could provide greater efficacy for small- and middle-molecule clearances and acceptable potential risks, while phosphate removal is comparable.
机译：创新了中间稀释和混合稀释在线血液透析滤过（OL-HDF）技术，以克服两种标准技术的局限性，包括预稀释和后稀释。不幸的是，同一项研究中这两种新技术之间的正面对比仍然有限。此外，原始的中稀释和混合稀释OL-HDF需要特殊的透析器和特殊的机器。在本研究中，确定了简单的中间稀释液和简单的混合稀释液OL-HDF，旨在在普通血液透析（HD）中心进行临床使用。测量和比较了两种方式之间尿毒症毒素去除的效率。这项前瞻性随机交叉研究是对12位稳定的HD患者进行的，这些患者接受简单的混合稀释和简单的中间稀释OL-HDF技术。在两种技术中，HD处方均相似。通过计算小分子（尿素，肌酐和磷酸盐）和中等分子（β-2微球蛋白[β2M]）的去除率来确定透析效率。此外，还观察到潜在的并发症，例如高跨膜压（TMP）和蛋白质损失。与简单的中间稀释OL-HDF技术相比，简单的混合稀释OL-HDF可提供更大的尿素，肌酐和β2M清除率。两种技术中的磷酸盐清除率均相当。此外，TMP和透析液白蛋白损失没有差异。两种技术都没有透析内并发症。简单的混合稀释OL-HDF可以为中小分子清除和可接受的潜在风险提供更大的功效，而磷酸盐的去除却具有可比性。

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