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首页> 外文期刊>Artificial Organs >Hemiarthroplasty of the Shoulder Joint Using a Custom-Designed High-Density Nano-Hydroxyapatite/Polyamide Prosthesis With a Polyvinyl Alcohol Hydrogel Humeral Head Surface in Rabbits
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Hemiarthroplasty of the Shoulder Joint Using a Custom-Designed High-Density Nano-Hydroxyapatite/Polyamide Prosthesis With a Polyvinyl Alcohol Hydrogel Humeral Head Surface in Rabbits

机译：定制设计的高密度纳米羟基磷灰石/聚酰胺假体与聚乙烯醇水凝胶肱骨头顶面的肩关节置换术

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摘要

In this study, a novel custom-designed high-density nano-hydroxyapatite/polyamide (n-HA/PA) prosthesis with a polyvinyl alcohol (PVA) hydrogel humeral head surface was employed to repair the shoulder joint head for hemiarthroplasty in rabbits. The prosthesis was fabricated using three-dimensional computed tomography and computer-aided design and computer-aided manufacturing systems for perfect fitting. Sixteen New Zealand white rabbits underwent humeral head excision, and received the composite prostheses for hemiarthroplasty. The implant sites were free from suppuration and necrosis at all periods. The X-ray results showed that there was a clear space between the prosthesis head and the glenoid surface, and the joint capsules and surfaces of the glenoid and PVA were well preserved without any damage during the whole inspection period. A high density of bone was observed around the firmware part of the prosthesis. Histological results revealed that significant osteogenesis was surrounding the firmware part, and the joint space was clear and the cartilage of the upper joint surface was basically intact. There was no visible absorption of the joint surfaces even after 3 months of continuous functional motions. The maximum tensile strength between the prosthesis and host bone reached 2.63MPa at the 12th week postimplantation. In conclusion, the customized prosthesis by combination of PVA and high-density n-HA/PA has excellent biocompatibility and biological fixation, and offers a promising substitute for both the cartilage and the bone of the humeral head in a rabbit model as level V evidence.
机译：在这项研究中，采用新型定制设计的高密度纳米羟基磷灰石/聚酰胺（n-HA / PA）假体与聚乙烯醇（PVA）水凝胶肱骨头表面修复兔肩关节，进行半髋关节置换术。使用三维计算机断层扫描和计算机辅助设计以及计算机辅助制造系统制造假体，以实现完美的配合。十六只新西兰白兔接受肱骨头切除术，并接受复合假体进行半髋关节置换术。植入部位在所有时期均无化脓和坏死。 X射线检查结果表明，假体头部和关节盂表面之间有一个清晰的空间，关节囊以及关节盂和PVA的表面得到了很好的保护，在整个检查过程中均未受到任何损坏。在假体的固件部分周围观察到高密度的骨头。组织学结果表明，固件部分周围有明显的成骨作用，关节间隙清晰，关节上表面的软骨基本完整。即使连续运动3个月后，关节表面也没有可见的吸收。植入后第12周，假体与宿主骨之间的最大抗拉强度达到2.63MPa。总之，结合PVA和高密度n-HA / PA的定制假体具有出色的生物相容性和生物固定性，并有望在兔模型中作为V级证据替代肱骨头的软骨和骨头。

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