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首页> 外文期刊>Artificial Organs >Comparison of sustained low-efficiency dialysis with acetate-free and acetate-containing bicarbonate dialysate in unstable patients
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Comparison of sustained low-efficiency dialysis with acetate-free and acetate-containing bicarbonate dialysate in unstable patients

机译：不稳定患者使用无乙酸盐和含乙酸盐的碳酸氢盐透析液进行持续低效率透析的比较

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摘要

This work is focused on the problem of maintenance of intradialytic hemodynamic safety in unstable patients with acute kidney injury (AKI). A hypothesis that "small" quantities of acetate in standard bicarbonate dialysate can cause pronounced acetatemia and exacerbate cardiovascular instability was tested. In this prospective randomized study, a group of patients with AKI after cardiac surgery was treated with sustained low-efficiency dialysis with either acetate-containing bicarbonate dialysate or acetate-free dialysate, where acetate is replaced by hydrochloric acid. It was demonstrated that application of acetate-containing bicarbonate dialysate results in blood acetate levels up to 12 times the normal level. Additionally, it is associated with a 3.8-fold-increased risk of hemodynamic complications in comparison with acetate-free dialysate. The choice of acetate-free or acetate-containing bicarbonate dialysate does not influence adequacy of correction of the acid-base and electrolyte content of blood.
机译：这项工作的重点是在不稳定的急性肾损伤（AKI）患者中维持透析内血液动力学安全性的问题。测试了一个假说，即标准碳酸氢盐透析液中少量的乙酸盐会导致明显的乙酸盐血症并加重心血管的不稳定性。在这项前瞻性随机研究中，对一组心脏手术后患有AKI的患者进行持续低效透析治疗，方法是用含乙酸盐的碳酸氢盐透析液或无乙酸盐的透析液（其中乙酸盐被盐酸代替）。已证明使用含乙酸盐的碳酸氢盐透析液可使血液中的乙酸盐水平达到正常水平的12倍。此外，与不含乙酸盐的透析液相比，它与血液动力学并发症的风险增加了3.8倍。不含乙酸盐或含乙酸盐的碳酸氢盐透析液的选择不会影响血液中酸碱和电解质含量校正的适当性。

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