Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart

Okamoto Eiji; Yano Tetsuya; Shiraishi Yasuyuki; Miura Hidekazu; Yambe Tomoyuki; Mitamura Yoshinori

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Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart

机译：使用与自然心脏串联的新型微型轴流泵进行初始急性动物实验

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We have advocated an axial flow blood pump called valvo pump that is implanted at the aortic valve position, and we have developed axial flow blood pumps to realize the concept of the valvo pump. The latest model of the axial flow blood pump mainly consists of a stator, a directly driven impeller, and a hydrodynamic bearing. The axial flow blood pump has a diameter of 33mm and length of 74mm, and the length of anatomical occupation is 33mm. The axial flow blood pump is anastomosed to the aorta with polytetrafluoroethylene (PTFE) cuffs worn on the inflow and outflow ports. Dp-Q curves of the axial flow blood pump are flatter than those of ordinary axial flow pumps, and pump outflow of 5L/min was obtained against a pressure difference of 50mmHg at a rotational speed of 9000rpm in vitro. The axial flow blood pump was installed in a goat by anastomosing with the thoracic descending aorta using PTFE cuffs, and it was rotated at a rotational speed of 8000rpm. Unlike in case of the ventricular assistance in parallel with the natural heart, pulsatilities of aortic pressure and aortic flow were preserved even when the pump was on, and mean aortic flow was increased by 1.5L/min with increase in mean aortic pressure of 30mmHg. In conclusion, circulatory assistance in series with the natural heart using the axial flow blood pump was able to improve hemodynamic pulsatility, and it would contribute to improvement of end-organ circulation.

机译：我们提倡将一种称为valvo泵的轴流式血泵植入主动脉瓣位置，并且我们已经开发了轴流式血泵来实现valvo泵的概念。最新型号的轴流血泵主要由一个定子，一个直接驱动的叶轮和一个动压轴承组成。轴流式血泵的直径为33mm，长度为74mm，解剖结构的长度为33mm。轴向流血泵通过流入和流出端口上的聚四氟乙烯（PTFE）袖套与主动脉吻合。轴流血泵的Dp-Q曲线比普通轴流泵的Dp-Q曲线平坦，并且在体外以9000rpm的转速对50mmHg的压差获得5L / min的泵流量。使用PTFE套囊通过将胸降主动脉吻合将轴流血泵安装在山羊中，并以8000rpm的转速旋转。与在自然心脏平行的情况下进行心室辅助的情况不同，即使在泵开启的情况下，主动脉压力和主动脉血流的搏动也得以保留，并且随着平均主动脉血压的增加30mmHg，平均主动脉血流以1.5L / min的速度增加。总之，使用轴流式血泵与自然心脏串联的循环辅助能够改善血液动力学脉搏，并有助于改善终末器官循环。

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《Artificial Organs》 |2015年第8期|共4页
作者
Okamoto Eiji; Yano Tetsuya; Shiraishi Yasuyuki; Miura Hidekazu; Yambe Tomoyuki; Mitamura Yoshinori;
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正文语种 eng
中图分类器官移植术;
关键词
Artificial heart; Ventricular assist device; Axial flow pump; Pulsatility;

机译：人造心脏;心室辅助装置;轴流泵;搏动性;

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1. Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart [J] . Okamoto Eiji, Yano Tetsuya, Shiraishi Yasuyuki, Artificial Organs . 2015,第8期

机译：使用与自然心脏串联的新型微型轴流泵进行初始急性动物实验
2. Improved hemodynamics with a novel miniaturized intra-aortic axial flow pump in a porcine model of acute left ventricular dysfunction [J] . ShabariF.R., GeorgeJ., CuchiaraM.P., ASAIO journal . 2013,第3期

机译：在急性左心功能不全的猪模型中使用新型微型主动脉内轴流泵改善血液动力学
3. Primary Left Ventricular Unloading with a Trans-valvular Axial Flow Pump Limits Ischemic Heart Failure After Acute Myocardial Infarction [J] . Reyelt Lara, Esposito Michele, Morine Kevin, Journal of the American College of Cardiology . 2017,第18期

机译：初级左心室卸载与逆瓣轴流泵限制急性心肌梗死后的缺血性心力衰竭
4. Noninvasive miniaturized mass-flow meter using a curved cannula for implantable axial flow blood pump [C] . Kosaka Ryo, Nishida Masahiro, Maruyama Osamu, 33rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2011

机译：使用弯曲插管的非侵入式微型质量流量计，用于植入式轴向流血泵
5. Estimation and control of the pump pressure rise and flow from intrinsic parameters for a magnetically-levitated axial blood pump. [D] . Khare, Aditi. 2008

机译：根据磁悬浮轴向血泵的固有参数估算和控制泵的压力上升和流量。
6. HeartWare Miniature Axial-Flow Ventricular Assist Device [O] . Mark S. Slaughter, Michael A. Sobieski II, Daniel Tamez, 2009

机译：HeartWare微型轴流心室辅助设备
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Initial Acute Animal Experiment Using a New Miniature Axial Flow Pump in Series With the Natural Heart

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