Microdialysis technique as a monitoring system for acute complications of diabetes.

Ciechanowska A; Ladyzynski P; Wojcicki JM; Sabalinska S; Krzymien J; Pulawska E; Karnafel W; Foltynski P; Kawiak J

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Microdialysis technique as a monitoring system for acute complications of diabetes.

机译：微透析技术作为糖尿病急性并发症的监测系统。

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The objective of the study was to establish the quasi-continuous courses, using microdialysis technique, of glucose, lactate, and glycerol concentrations in interstitial fluid of abdominal adipose tissue during the standard treatment of acute diabetes complications. Clinical studies were carried out on 31 diabetic patients during the initial 48 h of the treatment. In all but two obese female patients with hyperglycemic hyperosmolar state (HHS) did glucose concentration in perfusion fluid (PF) reflect concentration in capillary blood. The recovery of glucose correlated with patients' body mass index (r = 0.55). It was significantly higher in lean and overweight patients (91 +/- 15%) than in obese patients (55 +/- 31%). The course of lactate concentration in PF coincided with the course in venous blood (2.1 +/- 0.3 mmol/L vs. 2.0 +/- 0.5 mmol/L, P = 0.35). Glycerol concentration was 267 +/- 41 micromol/L and 133 +/- 40 micromol/L in PF and venous blood, respectively (P = 0.004). The study indicated that microdialysis may be an effective tool to monitor concentration of different metabolites in interstitial fluid of the adipose tissue during treatment of the acute complications of diabetes. Applicability of the technique in the monitoring of HHS, especially in obese female patients, needs further investigation.

机译：这项研究的目的是利用微透析技术建立在标准糖尿病急性并发症治疗过程中腹部脂肪组织间质液中葡萄糖，乳酸和甘油浓度的准连续过程。在治疗的最初48小时内，对31位糖尿病患者进行了临床研究。除两名肥胖的高血糖高渗状态（HHS）的肥胖女性患者外，灌注液（PF）中的葡萄糖浓度反映了毛细血管血液中的浓度。葡萄糖的恢复与患者的体重指数相关（r = 0.55）。肥胖和超重患者的肥胖率显着高于肥胖患者（55 +/- 31％）（91 +/- 15％）。 PF中乳酸浓度的变化过程与静脉血中的变化过程一致（2.1 +/- 0.3 mmol / L对2.0 +/- 0.5 mmol / L，P = 0.35）。 PF和静脉血中甘油的浓度分别为267 +/- 41 micromol / L和133 +/- 40 micromol / L（P = 0.004）。研究表明，微透析可能是监测糖尿病急性并发症治疗过程中脂肪组织间质中不同代谢物浓度的有效工具。该技术在HHS监测中的适用性，特别是在肥胖女性患者中，需要进一步研究。

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《Artificial Organs》 |2008年第1期|共7页
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Ciechanowska A; Ladyzynski P; Wojcicki JM; Sabalinska S; Krzymien J; Pulawska E; Karnafel W; Foltynski P; Kawiak J;
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正文语种 eng
中图分类医用一般科学;外科手术学;
关键词
Concentration; Complications Specific to Antepartum or Postpartum; Microdialysis; 微透析;

机译：浓度;产前或产后并发症;微透析;微透析;

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1. Microdialysis technique as a monitoring system for acute complications of diabetes. [J] . Ciechanowska A, Ladyzynski P, Wojcicki JM, Artificial Organs . 2008,第1期

机译：微透析技术作为糖尿病急性并发症的监测系统。
2. L'AUGMENTATION MAMMAIRE: INDICATIONS, TYPES DE PROTHÈSES, TECHNIQUES OPÉRATOIRES, COMPLICATIONS, RÉSULTATS [J] . SOPHIE BETTEX, MARIE-CHRISTINE GAILLOUD-MATTHIEU, WASSIM RAFFOUL, Revue Medicale de la Suisse Romande . 1999,第9期

机译：乳房增大：适应症，假体类型，手术技术，并发症，结果
3. Frequency of SMBG correlates with HbA1c and acute complications in children and adolescents with type 1 diabetes. [J] . Ziegler R, Heidtmann B, Hilgard D, Pediatric diabetes. . 2011,第1期

机译：SMBG的频率与HbA1c和1型糖尿病儿童和青少年的急性并发症相关。
4. Utilization of Low-profile Intra-aortic Balloon Catheters Inserted by the Sheathless Technique in Acute Cardiac Patients: High Efficacy with a Low Complication Rate [C] . S. Meisel, M. Shochat, S. Abu Sheikha, International Congress on Coronary Artery Disease . 2003

机译：利用急性心脏病患者护套技术插入的低调内部主动脉囊导管：高疗效，并发症率低
5. Development of online microdialysis-microchip system for in vivo monitoring. [D] . Nandi, Pradyot. 2009

机译：在线微透析-微芯片系统的体内监测开发。
6. Recent trends in microdialysis sampling integrated with conventional and microanalytical systems for monitoring biological events: A review [O] . Pradyot Nandi, Susan M. Lunte -1

机译：微透析对传统和微量分类系统进行监测生物事件的微透析抽样的趋势：综述
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Microdialysis technique as a monitoring system for acute complications of diabetes.

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