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首页> 外文期刊>Artificial Organs >Transplantation of tissue-engineered osteochondral plug using cultured chondrocytes and interconnected porous calcium hydroxyapatite ceramic cylindrical plugs to treat osteochondral defects in a rabbit model.
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Transplantation of tissue-engineered osteochondral plug using cultured chondrocytes and interconnected porous calcium hydroxyapatite ceramic cylindrical plugs to treat osteochondral defects in a rabbit model.

机译：使用培养的软骨细胞和互连的多孔羟基羟基磷灰石陶瓷圆柱状栓塞移植组织工程化的骨软骨栓塞，以治疗兔模型中的骨软骨缺损。

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The purpose of this study was to evaluate the macroscopic and histological results of transplanting a tissue-engineered composite plug made of tissue-engineered cartilage and interconnected porous calcium hydroxyapatite ceramics (IP-CHA) with a very high porosity of 94.9% to treat osteochondral defects. Twelve 12-week-old male Japanese white rabbits were used. Fresh articular cartilage slices were taken, and isolated chondrocytes (2 x 10(6) cells) were embedded in atelocollagen gel. They were seeded on the top of IP-CHA plugs and cultured for 2 weeks. These tissue-engineered composite plugs were transplanted into the osteochondral defects in the patellar grooves (the experimental group). In the control group, the defects were treated with composite plugs without chondroytes. Twelve weeks after transplantation in the experimental group, the defects were repaired with cartilage-like tissue with good subchondral bone formation histologically. Histological scores in the experimental group were significantly better than those in the control group. This study clearly showed the defects that had been treated with tissue-engineered composite plugs.
机译：这项研究的目的是评估由组织工程软骨和互连多孔羟基羟基磷灰石陶瓷（IP-CHA）制成的组织工程复合材料堵头的移植的宏观和组织学结果，孔隙率高达94.9％，可治疗骨软骨缺损。使用了十二只12周大的雄性日本白兔。取新鲜的关节软骨切片，并将分离的软骨细胞（2 x 10（6）细胞）包埋在telelocollagen凝胶中。将它们播种在IP-CHA塞子的顶部，并培养2周。这些组织工程复合塞被移植到pa骨沟的骨软骨缺损中（实验组）。在对照组中，用无软骨的复合栓塞治疗缺损。实验组移植十二周后，用软骨样组织修复缺损，组织学上软骨下骨形成良好。实验组的组织学评分明显优于对照组。这项研究清楚地表明了用组织工程复合材料栓塞治疗过的缺陷。

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