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首页> 外文期刊>Artificial Organs >Asymptomatic atherosclerosis and hypertension in nondiabetic patients with chronic kidney disease.
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Asymptomatic atherosclerosis and hypertension in nondiabetic patients with chronic kidney disease.

机译：非糖尿病慢性肾脏病患者的无症状动脉粥样硬化和高血压。

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摘要

Atherosclerosis is accelerated in dialysis patients, but less is known about asymptomatic atherosclerosis and major risk factors in patients with different stages of chronic kidney disease (CKD). We compared intima media thickness (IMT) and plaque occurrence in the carotid arteries in 104 nondiabetic patients (stages 1-5 of CKD; mean age: 51.6 years) with those in 40 healthy control subjects. The IMT values (0.69 vs. 0.59 mm; P < 0.002) were higher in patients. More patients had plaques (46.2 vs. 17.5%; P < 0.002), and number of plaques was higher (P < 0.003). Negative correlation between IMT (P < 0.0001), presence of plaques (P < 0.0001), their number (P < 0.040), and chromium 51-labeled ethylenediaminetetraacetate ((51)Cr-EDTA) clearance were found in patients. With multiple regression analysis, relationship between IMT and (51)Cr-EDTA clearance (P < 0.001) and presence of hypertension (P < 0.001) was found. Nondiabetic patients with CKD showed advanced atherosclerosis and IMT, plaque occurrence, andnumber increased directly with the level of renal dysfunction. Another important risk factor was hypertension.
机译：透析患者的动脉粥样硬化会加速，但是对于慢性肾脏病（CKD）不同阶段的患者，无症状动脉粥样硬化和主要危险因素的了解较少。我们比较了104名非糖尿病患者（CKD 1-5期;平均年龄：51.6岁）与40名健康对照者的颈动脉内膜中层厚度（IMT）和斑块发生情况。患者的IMT值（0.69 vs. 0.59 mm; P <0.002）更高。有斑块的患者更多（46.2比17.5％; P <0.002），斑块数量更高（P <0.003）。在患者中发现IMT（P <0.0001），斑块存在（P <0.0001），斑块数量（P <0.040）和铬51标记的乙二胺四乙酸盐（（51）Cr-EDTA）清除率之间呈负相关。通过多元回归分析，发现IMT和（51）Cr-EDTA清除率（P <0.001）与高血压的存在（P <0.001）之间的关系。非糖尿病性CKD患者表现出晚期动脉粥样硬化和IMT，斑块发生，数量随肾功能障碍程度的增加而直接增加。另一个重要的危险因素是高血压。

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