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首页> 外文期刊>Artificial Organs >Assessment of five interleukins in human synovial fluid as possible markers for aseptic loosening of hip arthroplasty.
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Assessment of five interleukins in human synovial fluid as possible markers for aseptic loosening of hip arthroplasty.

机译：评估人滑液中的五种白介素，作为髋关节置换术无菌性松动的可能标志。

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One of the most important factors that seems to be involved in total hip replacement is periprosthetic osteolysis. As it is well documented that several interleukins (ILs) are triggered in periprosthetic osteolysis, this article investigates the role of five ILs in primary and replacement total hip arthroplasty, understanding if one of them can also predict hip implant loosening, secondary surgery, and prosthesis breakage. The levels of IL-1alpha, 1beta, 6, 8, and 10 in synovial fluid were examined, using a high sensitivity enzyme-linked immunosorbent assay (ELISA) test kit (Pierce Biotechnology, Inc., Rockford, IL, USA) to determine whether these cytokines could be used as markers of enhanced periprosthetic osteolysis, leading to aseptic loosening of total/partial hip arthroplasty or revision surgery. Synovial fluid was harvested from 23 patients undergoing primary total hip arthroplasty and 35 patients undergoing total/partial hip revision due to aseptic loosening. In the revision group, four cases had suffered a prosthesis fracture and five were second revisions. ILs 6 and 8 were significantly higher in the revisions (305 and 817 pg/mL) compared with the primary arthroplasties (151 and 151 pg/mL), including cases with prosthesis fracture and those requiring a second revision. IL-10 levels were lower (not significantly) in second revision samples compared with those of revision samples. IL-1beta levels were significantly higher in prosthesis fracture samples compared with those of all the other revision samples. No statistically significant differences in IL levels were found between osteoarthritis samples and those of other diseases. These results are a step forward to elucidating the complex network of events that are involved in loosening of hip implants.
机译：似乎与全髋关节置换有关的最重要因素之一是假体周围的骨溶解。众所周知，假体周围骨溶解触发了几种白介素（IL），本文探讨了五个IL在原发性和置换性全髋关节置换术中的作用，了解其中之一是否也可以预测髋关节植入物的松动，继发性手术和假体破损。使用高灵敏度酶联免疫吸附测定（ELISA）测试试剂盒（Pierce Biotechnology，Inc.，Rockford，IL，USA）检查滑膜液中IL-1alpha，1beta，6、8和10的水平，以确定这些细胞因子是否可用作增强假体周围骨溶解的标志物，从而导致全髋/部分髋关节置换术或翻修手术的无菌性松动。由于无菌性松动，从23例行原发性全髋关节置换术的患者和35例行全髋/部分髋关节翻修的患者中收集滑液。在修订组中，有4例假体骨折，其中5例为第二修订版。与人工关节置换术（151和151 pg / mL）相比，修订版中的ILs 6和IL 8显着更高（305和817 pg / mL），包括假体骨折的病例和需要第二次修订版的ILs。与修订样本相比，第二修订样本中的IL-10水平较低（不显着）。与所有其他修订版样本相比，假体骨折样本中的IL-1beta水平明显更高。骨关节炎样本与其他疾病的样本之间，IL水平无统计学差异。这些结果是朝阐明涉及髋植入物松动的复杂事件网络迈出的一步。

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