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首页> 外文期刊>Asian-Australasian Journal of Animal Sciences >Rapamycin Inhibits Expression of Elongation of Very-long-chain Fatty Acids 1 and Synthesis of Docosahexaenoic Acid in Bovine Mammary Epithelial Cells
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Rapamycin Inhibits Expression of Elongation of Very-long-chain Fatty Acids 1 and Synthesis of Docosahexaenoic Acid in Bovine Mammary Epithelial Cells

机译：雷帕霉素抑制牛乳腺上皮细胞中超长链脂肪酸1的表达和二十二碳六烯酸的合成

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摘要

Mammalian target of rapamycin complex 1 (mTORC1) is a central regulator of cell growth and metabolism and is sufficient to induce specific metabolic processes, including de novo lipid biosynthesis. Elongation of very-long-chain fatty acids 1 (ELOVL1) is a ubiquitously expressed gene and the product of which was thought to be associated with elongation of carbon (C) chain in fatty acids. In the present study, we examined the effects of rapamycin, a specific inhibitor of mTORC1, on ELOVL1 expression and docosahexaenoic acid (DHA, C22:6 n-3) synthesis in bovine mammary epithelial cells (BMECs). We found that rapamycin decreased the relative abundance of ELOVL1 mRNA, ELOVL1 expression and the level of DHA in a time-dependent manner. These data indicate that ELOVL1 expression and DHA synthesis are regulated by mTORC1 in BMECs.
机译：雷帕霉素复合物1（mTORC1）的哺乳动物靶标是细胞生长和代谢的中央调节剂，足以诱导特定的代谢过程，包括从头合成脂质。超长链脂肪酸1（ELOVL1）的延伸是一个普遍表达的基因，其产物被认为与脂肪酸中碳（C）链的延伸有关。在本研究中，我们检查了雷帕霉素（一种mTORC1的特异性抑制剂）对牛乳腺上皮细胞（BMEC）中ELOVL1表达和二十二碳六烯酸（DHA，C22：6 n-3）合成的影响。我们发现雷帕霉素以时间依赖性方式降低了ELOVL1 mRNA，ELOVL1表达和DHA水平的相对丰度。这些数据表明在BMEC中，ELOVL1表达和DHA合成受mTORC1调控。

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