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首页> 外文期刊>Brain, behavior and evolution >Sex-specific modulation of cell proliferation by socially relevant stimuli in the adult green treefrog brain (Hyla cinerea).
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Sex-specific modulation of cell proliferation by socially relevant stimuli in the adult green treefrog brain (Hyla cinerea).

机译：成年绿色树蛙大脑（Hyla cinerea）中社会相关刺激对细胞增殖的性别特异性调节。

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Social experience plays an important role in regulating the neural, physiological and hormonal changes that accompany the expression of reproductive behavior in vertebrates. This suite of functions is sexually dimorphic, with different neural control areas preeminent in males and females. In anuran amphibians, social experience comes in the form of acoustic communication, which is central to their reproductive behavior. We sought to determine whether acoustic cues regulate cell proliferation in the brain of adult green treefrogs (Hyla cinerea). Our results show that both male and female treefrogs that heard a conspecific chorus during the breeding season exhibited increased brain cell proliferation compared to animals that heard random tones. Increased cell proliferation, as assessed by the number of 5-bromo-2'-deoxyuridine-immunoreactive (BrdU+) cells, were found near the ventricles of acoustically sensitive brain regions such as the preoptic area (POA) and the infundibular hypothalamus (IF). Sex differences emerged in the location of this socially modulated cell proliferation: increases occurred primarily in the male POA and the female IF. In addition, gonadal steroid hormones might have played a role in the social modulation of cell proliferation: by statistically control- ling for hormone level, we revealed that androgens might influence socially induced increases in BrdU+ cells in the male POA, but estrogen did not contribute to socially induced increases in the female IF. These results indicate that the reception of social cues increases cell proliferation in brain regions mediating sexual behavior and endocrine regulation, and moreover that social modulation of cell proliferation occurs in a sexually differentiated fashion.
机译：社会经验在调节伴随脊椎动物生殖行为表达的神经，生理和激素变化中起着重要作用。这套功能是两性性行为，男性和女性具有不同的神经控制区域。在无双栖动物的两栖动物中，社会经验以声音交流的形式出现，这对它们的生殖行为至关重要。我们试图确定声音提示是否调节成年绿色树蛙（Hyla cinerea）大脑中的细胞增殖。我们的研究结果表明，相比于听到随机声音的动物，在繁殖季节听到特定合唱的雄性和雌性树蛙均表现出增强的脑细胞增殖。在听觉敏感的大脑区域（如视前区（POA）和漏斗下丘脑（IF））的心室附近，发现了5-溴-2'-脱氧尿苷-免疫反应（BrdU +）细胞的数量，从而增加了细胞增殖。 。性别差异出现在这种受社会调节的细胞增殖的位置：增加主要发生在男性POA和女性IF中。另外，性腺类固醇激素可能在细胞增殖的社会调节中起作用：通过统计学控制激素水平，我们发现雄激素可能影响男性POA中社会诱导的BrdU +细胞的增加，但雌激素没有作用导致女性中频社交增加。这些结果表明，社交线索的接收增加了介导性行为和内分泌调节的脑区域中的细胞增殖，并且此外，细胞增殖的社会调节以性别区分的方式发生。

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