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首页> 外文期刊>Annals of Human Genetics >Common Variants in FTO Are Not Significantly Associated with Obesity-Related Phenotypes among Samoans of Polynesia
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Common Variants in FTO Are Not Significantly Associated with Obesity-Related Phenotypes among Samoans of Polynesia

机译：FTO的常见变体与波利尼西亚萨摩亚人的肥胖相关表型没有显着相关性

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摘要

The association between obesity and the fat mass and obesity-associated (FTO) gene has been widely replicated among Caucasian populations. The limited number of studies assessing its significance in Asian populations has been somewhat conflicting. We performed a genetic association study of 51 tagging, genome-wide association studies, and imputed single nucleotide polymorphisms with 12 measures of adiposity and skeletal robustness in two Samoan populations of Polynesia. We included 465 and 624 unrelated American Samoan and Samoan individuals, respectively; these populations derive from a single genetic background traced to Southeast Asia and represent one sociocultural unit, although they are economically disparate with distinct environmental exposures. American Samoans were significantly larger than Samoans in all measures of obesity and most measures of skeletal robustness. In separate analyses of American Samoa and Samoa, we found a total of 36 nominal associations between FTO variants and skeletal and obesity measures. The preponderance of these nominal associations (32 of 36) was observed in the Samoan population, and predominantly with skeletal rather than fat mass measures (28 of 36). All significance disappeared, however, following corrections for multiple testing. Based on these findings, it could be surmised that FTO is not likely a major obesity locus in Polynesian populations.
机译：肥胖与肥胖和肥胖相关（FTO）基因之间的关联已在白种人人群中广泛复制。评估其在亚洲人群中的重要性的研究数量有限，这在某种程度上是矛盾的。我们进行了一项基因标记研究，涉及51个标签，全基因组关联研究，以及推算出的单核苷酸多态性和12种测量方法在两个波利尼西亚萨摩亚人口中的肥胖和骨骼健壮性。我们分别包括465名和624名无关的美国萨摩亚人和萨摩亚人;这些种群虽然在经济上与独特的环境暴露截然不同，但它们源自追溯到东南亚的单一遗传背景，代表着一个社会文化单位。在所有肥胖程度和大多数骨骼健壮性方面，美属萨摩亚人都比萨摩亚人大。在对美属萨摩亚和萨摩亚的单独分析中，我们发现FTO变异与骨骼和肥胖测量之间共有36个名义上的关联。在萨摩亚人口中观察到这些名义关联的最多（36个中的32个），并且主要采用骨骼而非脂肪量度（36个中的28个）。但是，经过多次测试的更正后，所有意义都消失了。根据这些发现，可以推测FTO可能不是波利尼西亚人群的主要肥胖源。

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