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首页> 外文期刊>Annals of Human Genetics >Geographical Variations in TP53 Mutational Spectrum in Ovarian Carcinomas
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Geographical Variations in TP53 Mutational Spectrum in Ovarian Carcinomas

机译：卵巢癌中TP53突变谱的地理变异

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The TP53 gene mutational spectrum in human tumours shows variations related to tissue of origin, carcinogen exposure or molecular background. We have compared TP53 mutations in ovarian carcinomas from different geographical regions; this study was based on data extracted and verified from the IARC database (RIO, 2005), and on our results from 127 carcinomas. In total 873 mutation's were evaluated,. Tumours from Japan and Korea had a higher frequency of exon 7 mutations (38% us 25%, p = 0,011) and lower frequency of exon 8 mutations (11% vs 29%, p = 0,0003) than those from Western countries; they were particularly different from Norwegian tumours which showed the lowest proportion of exon 7 (19%, p = 0.001) and highest proportion of exon 8 (37%, p < 0,0001) mutations. There were also differences in the profile of TP53 hotspots. The third hotspot in tumours from Poland was amino acid (AA) 176 (8 2% of substitutions vs 1.7% in other countries, p < 0.001), while in tumours from the UK it was AA 220 (8.9% vs 2.3%, p < 0.001). Codon 27.3 was the only apparent hotspot in the Norwegian tumours, while it was rarely mutated in Polish and Asian tumours. In contrast to other data tumours from Norway presented with 273~(HIS) codon (82% of mutations at AA 27.3, p = 0.002), while tumours from the UK shared the 273 codon (80%, p < 0.001) Further analysis of TP53 gene mutations in ovarian cancer by geography could provide greater insights.
机译：人肿瘤中的TP53基因突变谱显示出与起源组织，致癌物暴露或分子背景有关的变异。我们比较了来自不同地理区域的卵巢癌中的TP53突变;这项研究基于从IARC数据库中提取和验证的数据（RIO，2005年），以及我们从127种癌症中获得的结果。总共评估了873个突变。与西方国家相比，日本和韩国的外显子7突变发生率更高（38％25％，p = 0.011），外显子8突变发生率较低（11％vs 29％，p = 0.0003）。它们与挪威肿瘤特别不同，后者的外显子7突变比例最低（19％，p = 0.001），外显子8突变比例最高（37％，p <0.0001）。 TP53热点的配置文件也存在差异。来自波兰的肿瘤中的第三个热点是氨基酸（AA）176（8 2％的替代，而其他国家中的1.7％，p <0.001），而来自英国的肿瘤中的氨基酸是AA 220（8.9％vs，2.3％，p）。 <0.001）。密码子27.3是挪威肿瘤中唯一明显的热点，而在波兰和亚洲肿瘤中很少发生突变。与其他数据相比，来自挪威的肿瘤具有273〜（HIS）密码子（AA 27.3处82％的突变，p = 0.002），而来自英国的肿瘤具有273〜（HIS）密码子（80％，p <0.001）。卵巢癌中TP53基因突变的地理分布可能会提供更大的见解。

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