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首页> 外文期刊>Annals of Human Genetics >Length variability and interspersion patterns of the HRAS1 minisatellite: a new approach for the reconstruction of human population relationships.
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Length variability and interspersion patterns of the HRAS1 minisatellite: a new approach for the reconstruction of human population relationships.

机译：HRAS1小卫星的长度变异性和散布模式：重建人口关系的新方法。

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During recent years the HRAS1 minisatellite has been analysed by several authors because of its putative association with cancer susceptibility. The aim of this report is to test the usefulness of this minisatellite in investigating human population relationships. We have studied 370 chromosomes from two well-differentiated populations: Galicia (North-west Iberia) and South-east Africa, as well as available data on allele length gene frequencies. The fragment analysis results show a strong tendency to differentiate between non-African and African populations. In spite of the usefulness of fragment analysis, the minisatellite variant repeat (MVR) approach of the HRAS1 minisatellite appears to be a more powerful method for use in human population studies, due to the high level of diversity of its interspersion pattern structures. In addition, this approach has allowed us to define some new structural characteristics of this minisatellite. Four different major groups of human HRAS1 minisatellite alleles could be distinguished following a structural criterion based on the MVR code. Furthermore, the characterisation of the HRAS1 minisatellite in chimpanzees revealed clear differences when compared to humans, not only with respect to the allele size but also to the internal structure.
机译：近年来，由于HRAS1微型卫星与癌症易感性有关，已经对其进行了分析。本报告的目的是检验这种小型卫星在调查人口关系中的作用。我们已经研究了来自两个高度分化的群体的370条染色体：加利西亚（西北伊比利亚）和东南非洲，以及有关等位基因长度基因频率的可用数据。片段分析结果显示出很强的区分非非洲和非洲人口的趋势。尽管片段分析很有用，但HRAS1小卫星的小卫星变异重复（MVR）方法似乎更有效地用于人群研究，原因是其散布模式结构的多样性很高。另外，这种方法使我们能够定义这种小型卫星的一些新结构特征。遵循基于MVR代码的结构准则，可以区分人类HRAS1小卫星等位基因的四个不同主要类别。此外，与人类相比，黑猩猩中HRAS1小卫星的特征显示出明显的差异，不仅在等位基因大小方面，而且在内部结构方面。

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