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首页> 外文期刊>Atherosclerosis >Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats
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Red wine and equivalent oral pharmacological doses of resveratrol delay vascular aging but do not extend life span in rats

机译：红酒和等效的白藜芦醇口服药理剂量可延缓血管衰老，但不会延长大鼠的寿命

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Objective: To investigate, in male Wistar rats, the effects of long-term moderate red wine (RW) consumption (equivalent to ～0.15 mg% resveratrol RS), or RS in low (L, 0.15 mg%) or high (H, 400 mg%) doses in chow. Background: Both RW and RS exhibit cardioprotection. RS extends lifespan in obese rats. It is unclear whether RW consumption or low-dose RS delay vascular aging and prolong life span in the absence of overt risk factors. Methods: Endpoints were aerobic performance, exercise capacity, aging biomarkers (p53,p16,p21, telomere length and telomerase activity in aortic homogenates), vascular reactivity. Data were compared with controls (C) given regular chow. Results: Expressions of p53 decreased ～50% ～with RW and LRS (p 0.05 vs. C), p16 by ～29% with RW (p 0.05 vs. C) and p21 was unaltered. RW and LRS increased telomere length 6.5-fold vs. C, and telomerase activity increased with LRS and HRS. All treatments increased aerobic capacity (C 32.5 ± 1.2, RW 38.7 ± 1.7, LRS 38.5 ± 1.6, HRS 38.3 ± 1.8 mlO 2 min -1 kg -1), and RW or LRS also improved time of exercise tolerance vs. C (p 0.05). Endothelium-dependent relaxation improved with all treatments vs. C. Life span, however, was unaltered with each treatment vs. C = 673 ± 30 days, p = NS. Conclusions: RW and LRS can preserve vascular function indexes in normal rats, although not extending life span. These effects were translated into better aerobic performance and exercise capacity.
机译：目的：研究雄性Wistar大鼠长期饮用中度红酒（RW）的效果（相当于〜0.15 mg％白藜芦醇RS），或低（L，0.15 mg％）或高（H，H，剂量为400 mg％）。背景：RW和RS都表现出心脏保护作用。 RS延长了肥胖大鼠的寿命。尚不清楚在没有明显危险因素的情况下，RW消耗量或低剂量RS是否会延迟血管衰老并延长寿命。方法：终点是有氧运动能力，运动能力，衰老的生物标志物（p53，p16，p21，端粒长度和主动脉匀浆中的端粒酶活性），血管反应性。将数据与常规饮食的对照组（C）进行比较。结果：RW和LRS使p53的表达降低〜50％〜（p <0.05 vs. C），RW和pRS的表达使p16的表达降低〜29％（p <0.05 vs. C），而p21未改变。 RW和LRS与C相比，端粒长度增加> 6.5倍，并且端粒酶活性随LRS和HRS的增加而增加。所有治疗均提高了有氧运动能力（C 32.5±1.2，RW 38.7±1.7，LRS 38.5±1.6，HRS 38.3±1.8 mlO 2 min -1 kg -1），并且RW或LRS与C相比还改善了运动耐力时间（p <0.05）。与C相比，所有治疗均改善了内皮依赖性舒张。然而，与C = 673±30天，p = NS相比，每种治疗的寿命均未改变。结论：RW和LRS可以维持正常大鼠的血管功能指标，尽管不会延长寿命。这些影响转化为更好的有氧运动表现和运动能力。

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