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首页> 外文期刊>Atherosclerosis >Associations between alcohol consumption and selected cytokines in a Swiss population-based sample (CoLaus study)
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Associations between alcohol consumption and selected cytokines in a Swiss population-based sample (CoLaus study)

机译：一项基于瑞士人群的样本中的饮酒与某些细胞因子之间的关联（CoLaus研究）

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Objective: To assess the associations between alcohol consumption and cytokine levels (interleukin-1beta - IL-1β; interleukin-6 - IL-6 and tumor necrosis factor-α - TNF-α) in a Caucasian population. Methods: Population sample of 2884 men and 3201 women aged 35-75. Alcohol consumption was categorized as nondrinkers, low (1-6 drinks/week), moderate (7-13/week) and high (14+/week). Results: No difference in IL-1β levels was found between alcohol consumption categories. Low and moderate alcohol consumption led to lower IL-6 levels: median (interquartile range) 1.47 (0.70-3.51), 1.41 (0.70-3.32), 1.42 (0.66-3.19) and 1.70 (0.83-4.39). pg/ml for nondrinkers, low, moderate and high drinkers, respectively, p< 0.01, but this association was no longer significant after multivariate adjustment. Compared to nondrinkers, moderate drinkers had the lowest odds (Odds ratio = 0.86 (0.71-1.03)) of being in the highest quartile of IL-6, with a significant (p< 0.05) quadratic trend. Low and moderate alcohol consumption led to lower TNF-α levels: 2.92 (1.79-4.63), 2.83 (1.84-4.48), 2.82 (1.76-4.34) and 3.15 (1.91-4.73). pg/ml for nondrinkers, low, moderate and high drinkers, respectively, p< 0.02, and this difference remained borderline significant (p= 0.06) after multivariate adjustment. Moderate drinkers had a lower odds (0.81 [0.68-0.98]) of being in the highest quartile of TNF-α. No specific alcoholic beverage (wine, beer or spirits) effect was found. Conclusions: Moderate alcohol consumption is associated with lower levels of IL-6 and (to a lesser degree) of TNF-α, irrespective of the type of alcohol consumed. No association was found between IL-1β levels and alcohol consumption.
机译：目的：评估高加索人群饮酒与细胞因子水平（白介素-1β-IL-1β;白介素-6-IL-6和肿瘤坏死因子-α-TNF-α）之间的关系。方法：年龄为35-75岁的2884名男性和3201名女性的人口样本。饮酒分类为不饮酒，低（每周喝1-6杯酒），中度（每周喝7-13）和高（每周喝14+）。结果：饮酒类别之间的IL-1β水平没有差异。中度饮酒会导致IL-6水平降低：中位数（四分位数范围）1.47（0.70-3.51），1.41（0.70-3.32），1.42（0.66-3.19）和1.70（0.83-4.39）。非饮酒者，低，中度和高饮者的pg / ml分别为p <0.01，但是在进行多变量调整后，这种关联不再显着。与非饮酒者相比，中度饮酒者IL-6最高四分位数的几率最低（几率= 0.86（0.71-1.03）），并且呈二次方趋势（p <0.05）。中度饮酒会导致TNF-α水平降低：2.92（1.79-4.63），2.83（1.84-4.48），2.82（1.76-4.34）和3.15（1.91-4.73）。非饮酒者，低，中度和高饮者的pg / ml分别为p <0.02，经过多变量调整后，该差异仍处于临界水平（p = 0.06）。中度饮酒者处于TNF-α最高四分位数的几率较低（0.81 [0.68-0.98]）。没有发现特定的酒精饮料（葡萄酒，啤酒或烈性酒）效果。结论：适度饮酒与较低的IL-6水平和（较小程度的）TNF-α有关，而与饮酒类型无关。 IL-1β水平与饮酒量之间没有关联。

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