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首页> 外文期刊>Annales de biologie clinique >Advances in thyroglobulin assays and their impact on the management of differentiated thyroid cancers
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Advances in thyroglobulin assays and their impact on the management of differentiated thyroid cancers

机译：甲状腺球蛋白测定法的进展及其对分化型甲状腺癌管理的影响

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Thyroglobulin (Tg) is a high molecular weight glycoprotein located mainly in thyroid follicles, where thyroid hormones are synthesized and stored. In patients with differentiated thyroid cancer of follicular origin, serum Tg levels become undetectable following total thyroidectomy and iodine-131 remnant ablation. It is a key biomarker to follow-up patients with differentiated thyroid cancer, in combination with neck ultrasound monitoring. The measurement of Tg in the wash-out of the needle used for fine needle aspiration biopsy is a valuable aid to the diagnosis of lymph node metastasis. The presence of anti-thyroglobulin antibodies affects reliability of Tg results measured in serum or plasma. Systematic investigation of such antibodies is required to validate any Tg assay. Elevated or rising levels of anti-thyroglobulin antibodies can in turn be used as a surrogate tumor marker of thyroid cancer. The development of second-generation Tg assay (automated, highly sensitive) has enabled significant advances in the management of differentiated thyroid cancer: early detection of persistent or recurrent disease and follow-up care simplified in low-risk patients. Testing of serum Tg can also be useful in evaluating other clinical situations such as congenital hypothyroidism, endemic goiter and thyrotoxicosis factitia.
机译：甲状腺球蛋白（Tg）是一种高分子量的糖蛋白，主要位于甲状腺滤泡中，甲状腺激素在那里合成和储存。在患有滤泡性甲状腺癌的患者中，全甲状腺切除术和碘131残留消融后无法检测到血清Tg水平。与颈部超声监测相结合，它是随访分化型甲状腺癌患者的关键生物标志物。在用于细针穿刺活检的针洗出液中Tg的测量对淋巴结转移的诊断有重要的帮助。抗甲状腺球蛋白抗体的存在会影响在血清或血浆中测得的Tg结果的可靠性。需要对此类抗体进行系统研究以验证任何Tg分析。抗甲状腺球蛋白抗体水平升高或升高又可以用作甲状腺癌的替代肿瘤标志物。第二代Tg分析（自动，高度灵敏）的发展已使分化型甲状腺癌的管理取得了重大进展：持续性或复发性疾病的早期检测以及低风险患者的后续护理得到简化。血清Tg的检测也可用于评估其他临床情况，例如先天性甲状腺功能减退，地方性甲状腺肿和甲状腺毒症。

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