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首页> 外文期刊>Annales de biologie clinique >Biomarkers of neuroendocrine tumors
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Biomarkers of neuroendocrine tumors

机译:神经内分泌肿瘤的生物标志物

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Neuroendocrine tumors (NET) are rare heterogenous tumors which prevalence is increasing. Their features vary by anatomical location, functionality and hormonal production. Their management needs a multidisciplinary approach. Functional tumors develop characteristic clinical syndromes in contrast to non-functional tumors that are diagnosed fortuitously or at advanced stage. NET can secrete many specific and general biomarkers. CgA is the most sensitive general marker. Its value should be interpreted along with the renal function and the gastrin level. Some new biomarkers such as NTproBNP, proGRP and NET gene transcripts have been identified. The latter are not yet routine in clinical practice. We present In this review biological biomarkers involved in NET with a focus on the assays and their use in clinical practice.
机译:神经内分泌肿瘤(NET)是罕见的异质性肿瘤,其患病率正在增加。它们的特征因解剖位置,功能和荷尔蒙产生而异。他们的管理需要多学科的方法。与偶然或晚期诊断的非功能性肿瘤相反,功能性肿瘤发展为特征性临床综合征。 NET可以分泌许多特定和一般的生物标记。 CgA是最敏感的一般标记。其值应与肾功能和胃泌素水平一起解释。已经鉴定出一些新的生物标志物,例如NTproBNP,proGRP和NET基因转录物。后者在临床实践中还不是常规的。我们在这篇综述中介绍了涉及NET的生物生物标志物,重点是测定及其在临床实践中的用途。

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