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首页> 外文期刊>Annales de biologie clinique >Direct and indirect ion selective electrodes methods: the differences specified through a case of Waldenstrom's macroglobulinemia
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Direct and indirect ion selective electrodes methods: the differences specified through a case of Waldenstrom's macroglobulinemia

机译：直接和间接离子选择电极方法：通过Waldenstrom巨球蛋白血症病例确定的差异

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摘要

Direct and indirect ion selective electrodes (ISEs) are two methods commonly used in biochemistry laboratories in order to measure the electrolytes such as sodium. In the clinical practice, it's the sodium concentration in plasma water -measured by direct ISE-which is important to consider as it is responsible of water movements between the liquid compartments. Knowing the difference between the two methods is important because there are situations leading to conflicting results between direct and indirect ISE, especially with sodium and inappropriate therapeutic decisions could be taken if the clinician is not aware of this difference. The increase and the decrease in plasma water volume are the situations that distort the results of the indirect ISE because this method, after a dilution step, does not take into account the real percentage of plasma water of the patient in the determination of the concentrations (leading for sodium to pseudohyponatremia, pseudonormonatremia or pseudohypernatremia). In the direct ISE, the sample is not diluted and the results are correct even if the volume of plasma water is modified. This article specifies the differences between the two techniques through a case of Waldenstrom's macroglobulinemia and proposes a course of action to follow for both of the biologist and the clinician.
机译：直接和间接离子选择电极（ISE）是生物化学实验室中常用的两种方法，用于测量电解质（如钠）。在临床实践中，通过直接ISE测量的是血浆水中的钠浓度，这一点很重要，因为它负责液体室之间的水运动。知道这两种方法之间的差异很重要，因为在某些情况下，直接和间接ISE之间的结果会发生冲突，尤其是在使用钠的情况下，如果临床医生不了解这种差异，则可能会做出不合适的治疗决策。血浆水量的增加和减少是使间接ISE的结果失真的情况，因为此方法在稀释步骤后，在确定浓度时未考虑患者血浆水的真实百分比（导致钠导致假性低钠血症，假性正常尿酸血症或假性高钠血症）。在直接ISE中，即使修改了血浆水的体积，样品也不会被稀释并且结果是正确的。本文通过Waldenstrom巨球蛋白血症病例说明了两种技术之间的差异，并提出了生物学家和临床医生应遵循的行动方案。

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