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首页> 外文期刊>Australian Journal of Dairy Technology >Weight loss using meal replacements high in glycomacropeptide-enriched whey powder
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Weight loss using meal replacements high in glycomacropeptide-enriched whey powder

机译：使用富含糖巨肽的乳清粉替代膳食替代品可减轻体重

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摘要

Cholecystokinin (CCK) is a peptide hormone that causes gallbladder contraction and pancreatic enzyme secretion for the digestion of protein and fat. It is also thought to have a role in satiety. It has been reported that glycomacropeptide (GMP) stimulates the release of CCK and may contribute to increased satiety and reduced energy intake. The aim of this study was to examine after six months whether greater weight loss could be achieved with a GMP-enriched whey powder meal replacement compared to a skim milk protein powder meal replacement. In a randomised, double blind, parallel design, body composition measured by dual-energy X-ray absiorptiometry (DEXA) and cardiovascular disease (CVD) risk factors were measured at baseline and 6 months. The weight loss strategy used meal replacements (MR) containing 33 g protein from GMP-enriched-whey-protein-isolate, or skim-milk-protein-powder (SMPP) and 954kJ kJ/sachet. Volunteers were asked to consume 2 MR/day instead of 2 meals for 6 months. One hundred and twenty seven participants (34 men, 99 women, 95.5+/-15.4 kg, BMI 33.4+/-3.4 kg/m2, 50.0+/-12.4 yr) commenced and 82 completed the 6 month study. After 6 months weight loss was 9.5+/-5.8 vs 11.0+/-6.0 kg, GMP and SMPP respectively (p<0.001 compared with baseline) with no differences between treatments. Total and LDL-cholesterol, triglycerides, glucose, insulin, systolic and diastolic blood pressure decreased at 6 months (All p<0.01 compared with baseline with no difference between treatments). We conclude that weight loss using dairy protein-based meal replacements achieved a clinically meaningful weight loss with benefics on markers of CVD risk but GMP had no additional effect using this study design.
机译：胆囊收缩素（CCK）是一种肽激素，可引起胆囊收缩和胰酶分泌，以消化蛋白质和脂肪。它也被认为在饱腹感中起作用。据报道，糖巨肽（GMP）刺激CCK的释放，可能有助于增加饱腹感和减少能量摄入。这项研究的目的是检查六个月后，与脱脂牛奶蛋白粉代餐相比，富含GMP的乳清粉代餐能否实现更大的减肥效果。在随机，双盲，平行设计中，在基线和6个月时测量了通过双能X线骨密度仪（DEXA）和心血管疾病（CVD）危险因素测量的身体成分。减肥策略是使用膳食替代品（MR），其中包含33 g来自富含GMP的乳清蛋白粉或脱脂奶蛋白粉（SMPP）和954kJ kJ /小袋的蛋白质。志愿者被要求每天消耗2 MR而不是2餐，持续6个月。开始了一百二十七名参与者（34名男性，99名女性，95.5 +/- 15.4千克，BMI 33.4 +/- 3.4千克/平方米，50.0 +/- 12.4年），有82名参与者完成了为期6个月的研究。 6个月后，体重减轻分别为9.5 +/- 5.8 kg和11.0 +/- 6.0 kg，GMP和SMPP（与基线相比，p <0.001），治疗之间无差异。总和LDL胆固醇，甘油三酸酯，葡萄糖，胰岛素，收缩压和舒张压在6个月时降低（与基线相比，所有p <0.01，治疗之间无差异）。我们得出的结论是，使用基于乳蛋白的膳食替代品来减轻体重，对受益于CVD风险标志物的患者具有临床意义上的有意义的减肥，但是使用本研究设计，GMP没有其他作用。

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