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首页> 外文期刊>Australian infection control: official journal of the Australian Infection Control Association Inc >Comparative efficacy of medical instrument cleaning products in digesting some blood proteins
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Comparative efficacy of medical instrument cleaning products in digesting some blood proteins

机译：医疗仪器清洁产品在消化某些血液蛋白质中的比较功效

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摘要

The instrument-cleaning step is recognised as critical in achieving sterility or high-level disinfection in the medical instrument reprocessing cycle. Proteins in the residual bioburden on instruments after their use present a serious challenge to successful reprocessing, as they can adversely affect both chemical and physical sterilisation. The commercial products used in the cleaning step have a variety of functionalities, one of the most important of which is the elimination of human proteins from the instrument prior to the sterilisation/high level disinfection step.The methodology employed in this study is SDS-PAGE, a gel electrophoresis technique, which is a standard for determining protein molecular weights. Some proteins have low w-ater-solubility and can be reliably eliminated only when broken down into small water-soluble fragments. The study involves the comparison of protein molecular weights before and after treatment with various cleaning products to give a clear indication of protein digestion efficacy.The study concludes that many products claiming protein digestion properties have virtually no efficacy in this regard, whilst others tested are highly effective. This is alarming since most of the products tested claim 'removal of all proteins' within two minutes.
机译：仪器清洁步骤被认为是在医疗仪器后处理周期中实现无菌或高水平消毒的关键。仪器上残留的生物负载中的蛋白质使用后，对成功的再加工提出了严峻的挑战，因为它们会对化学和物理灭菌产生不利影响。清洁步骤中使用的商业产品具有多种功能，其中最重要的功能之一是在灭菌/高水平消毒步骤之前从仪器中消除人蛋白质。本研究中使用的方法是SDS-PAGE凝胶电泳技术，这是确定蛋白质分子量的标准。有些蛋白质的w-ater溶解度低，只有分解成小的水溶性片段后才能可靠地消除。这项研究包括比较各种清洁产品处理前后的蛋白质分子量，以清楚地表明蛋白质的消化功效。该研究得出的结论是，许多声称具有蛋白质消化特性的产品在这方面几乎没有功效，而其他测试产品的功效很高有效。这令人震惊，因为大多数测试产品声称在两分钟内“去除了所有蛋白质”。

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