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首页> 外文期刊>Auris, nasus, larynx >Fluctuating mixed-type hearing loss associated with synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome.
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Fluctuating mixed-type hearing loss associated with synovitis-acne-pustulosis-hyperostosis-osteomyelitis (SAPHO) syndrome.

机译：与滑膜炎，痤疮，脓疱病，肥大症，骨脊髓炎（SAPHO）综合征相关的混合型听力损失波动。

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摘要

Synovitis, acne, palmoplantar pustulosis (PPP), hyperostosis, and osteitis (SAPHO) are the characteristic features of SAPHO syndrome. A 53-year-old woman had been treated for PPP for 2 years. She complained of hearing loss in the right ear, and otitis externa was diagnosed. The pure-tone audiogram (PTA) indicated mild hearing loss in the right ear, and her hearing continued to deteriorate despite recovery from inflammation. Her tympanogram was of the As-type, and acoustic reflex was absent in the right ear. A computed tomography (CT) scan revealed bilateral normal ossicles and cochleas. Bone scintigraphy revealed tracer uptake in the bilateral sternoclavicular joints, glenohumeral joints, and the capital humerus. She was hospitalized for arthralgia, and the pain was controlled with steroid therapy. Her right hearing deteriorated soon after the tapering of the steroid; her hearing recovered after cyclosporine therapy was initiated. The first tonsil provocation test showed increased blood cells in the urine, and the second test showed exacerbation of pustulosis. Despite immunosuppressant therapy, the arthritis attacks and hearing loss persisted; therefore, tonsillectomy was performed, which improved PPP. However, her hearing remained unchanged after the operation. We considered that irreversible changes might have already developed in the ossicular joints, and ossicular reconstruction was performed. Thereafter, her hearing and earache improved.
机译：滑膜炎，痤疮，掌plant脓疱病（PPP），骨肥大和骨炎（SAPHO）是SAPHO综合征的特征。一名53岁的妇女因PPP接受了2年的治疗。她抱怨右耳听力下降，并诊断出外耳道炎。纯音听力图（PTA）表示右耳轻度听力下降，尽管炎症已恢复，但听力仍在恶化。她的鼓室图为As型，右耳无声反射。计算机断层扫描（CT）扫描显示双侧正常听小骨和耳蜗。骨闪烁显像显示双侧肩锁关节，盂肱关节和肱骨的示踪剂摄取。她因关节痛住院，并且使用类固醇疗法控制了疼痛。类固醇逐渐减少后，她的右耳听力下降;开始环孢霉素治疗后，她的听力恢复了。第一次扁桃体刺激试验显示尿液中血细胞增加，第二次试验显示脓疱病加重。尽管进行了免疫抑制剂治疗，但关节炎发作和听力损失仍持续存在。因此，进行扁桃体切除术可改善PPP。但是，手术后她的听力保持不变。我们认为听骨关节可能已经发生了不可逆的变化，并进行了听骨重建。此后，她的听力和耳痛得到改善。

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