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首页> 外文期刊>Biocontrol Science >Preserved and unpreserved 12 anti-allergic ophthalmic solutions and ocular surface toxicity: in vitro assessment in four cultured corneal and conjunctival epithelial cell lines.
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Preserved and unpreserved 12 anti-allergic ophthalmic solutions and ocular surface toxicity: in vitro assessment in four cultured corneal and conjunctival epithelial cell lines.

机译：保留和未保留的12种抗过敏眼药水和眼表毒性：在体外培养的4种角膜和结膜上皮细胞系中进行体外评估。

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摘要

In the present study, we evaluated the cytotoxicity of anti-allergic ophthalmic solutions in cultured corneal and conjunctival cells, namely SIRC (rabbit corneal epithelium), BCE C/D-1b (bovine corneal epithelial cells), RC-1 (rabbit corneal epithelium), and Chang (human conjunctival cells). The viability of cell cultures was determined following the exposure of cells to 12 commercially available anti-allergic ophthalmic solutions for varying exposure times and at various dilutions using the MTT and neutral red assays. The cell viability score (CVS) was used to compare the toxicity of different drugs. Based on CVS data, the order of cell viability after exposure to the drugs was Zepelin >= Tramelas PF >= Cumorol PF >= Ketotifen PF >= Eyevinal = Fumarton >= Cumorol > Intal >= Rizaben >= Tramelas >= Patanol Livostin. In conclusion, cell viability was mostly affected by the concentration of benzalkonium chloride rather than the active component and/or the anti-allergic action of the drug. The CVS was useful in comparing the toxicity of different drugs.
机译：在本研究中，我们评估了抗过敏眼药水在培养的角膜和结膜细胞（即SIRC（兔角膜上皮），BCE C / D-1b（牛角膜上皮细胞），RC-1（兔角膜上皮））中的细胞毒性。 ）和Chang（人结膜细胞）。使用MTT和中性红测定法，将细胞暴露于12种市售抗过敏眼药溶液中，以改变暴露时间，并以各种稀释度稀释后，确定细胞培养物的活力。细胞生存力分数（CVS）用于比较不同药物的毒性。根据CVS数据，暴露于药物后的细胞活力顺序为Zepelin> = Tramelas PF> = Cumorol PF> = Ketotifen PF> = Eyevinal = Fumarton> = Cumorol> Intal> = Rizaben> = Tramelas> = Patanol Livostin。总之，细胞生存力主要受苯扎氯铵浓度而不是药物的活性成分和/或抗过敏作用的影响。 CVS可用于比较不同药物的毒性。

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