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首页> 外文期刊>Auris, nasus, larynx >Expression of myelin basic protein in the human auditory nerve - an immunohistochemical and comparative study.
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Expression of myelin basic protein in the human auditory nerve - an immunohistochemical and comparative study.

机译：髓磷脂碱性蛋白在人听神经中的表达-免疫组化和比较研究。

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OBJECTIVE: The aim of this study is to analyse the expression and distribution of myelin basic protein (MBP or Myelin A1 protein) in the human spiral ganglion and auditory nerve. MATERIALS AND METHODS: Cryostat sections were made from freshly fixed human cochlear specimens removed at surgery in patients with life-threatening petro-clival meningiomas compressing the brain stem. The sections were subjected to immunohistochemistry using antibodies against MBP, S-100 and Tubulin. The immunoreaction was documented using laser confocal microscopy. RESULTS: Type I spiral ganglion nerve somata (SGN) were surrounded by so-called "satellite glial cells" (SGCs) that lacked expression of MBP consistent with earlier light and electron microscopic findings indicating that these cells are non-myelinating. S-100 labeling showed that the SGCs form a continuous network in the apical region. CONCLUSIONS: The pattern of myelination in human spiral ganglion is different from that in other species' spiral ganglion. The striking differences in myelin outline should be investigated further in combination with its influence on signal coding and preservation properties in man.
机译：目的：本研究旨在分析人螺旋神经节和听神经中髓鞘碱性蛋白（MBP或Myelin A1蛋白）的表达和分布。材料与方法：冷冻切片是由新鲜固定的人耳蜗标本制成的，该标本是在危及生命的岩石斜坡脑膜瘤压迫脑干的患者手术时取出的。使用抗MBP，S-100和微管蛋白的抗体对切片进行免疫组织化学。使用激光共聚焦显微镜记录了免疫反应。结果：I型螺旋神经节神经索马索（SGN）被所谓的“卫星神经胶质细胞”（SGCs）包围，这些细胞缺乏MBP的表达，这与早期的光镜和电子显微镜检查结果一致，表明这些细胞是非髓鞘的。 S-100标记显示SGC在根尖区域形成连续网络。结论：人螺旋神经节的髓鞘形成模式不同于其他物种的螺旋神经节。应结合髓鞘对人信号编码和保存特性的影响，进一步研究髓鞘轮廓上的显着差异。

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