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Bacteriostatic and bactericidal actions of antimicrobial drugs studied by microbial calorimetry

机译：微生物量热法研究抗菌药物的抑菌和杀菌作用

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摘要

Antimicrobial actions of p-hydroxybenzoate alkyl esters (parabens) and two formalin derivatives, Quarternium 15 (Q15) and imidazolidinyl urea (IDU), which are commonly used in cosmetics and toiletries as preservatives or bactericides, were evaluated against Klebsiella pneumoniae using a technique of microbial calorimetry. With parabens, which are known to have bacteriostatic actions, increased concentrations caused changes in the growth thermograms of the microorganism characterized by a suppression in the slopes at the exponential growth phase. In contrast, with Q15 and IDU, which are known to have rather strong bactericidal effects the growth thermograms shifted toward a longer incubation time in proportion to the drug concentration while their shapes were unchanged. These two types of actions were compared in terms of two indexes: the changes in the growth rate constant and in the apparent growth retardation. In the case of bacteriostatic drugs such as parabens, antimicrobial actions resulted in the growth retardation due to the lowering of the growth rate constant. In contrast, bactericidal drugs such as formalin preservatives did not affect the growth rate constant and caused only an apparent retardation in growth. The observed difference in the change of growth thermogram patterns is discussed in terms of a difference in the two drug potency curves drawn on the basis of the two indexes.
机译：对对羟基苯甲酸酯烷基酯（对羟基苯甲酸酯）和两种福尔马林衍生物季铵盐15（Q15）和咪唑烷基尿素（IDU）的抗菌作用进行了评估，该技术使用以下技术对化妆品和盥洗用品中的防腐剂或杀菌剂进行了评估：微生物量热法。使用已知具有抑菌作用的对羟基苯甲酸酯，浓度升高会导致微生物的生长温度谱图发生变化，其特征是在指数生长期的斜率受到抑制。相反，已知Q15和IDU具有较强的杀菌作用，其生长温度记录图与药物浓度成比例地向更长的孵育时间移动，而形状不变。根据两种指标比较了这两种类型的作用：生长速率常数的变化和表观生长迟缓。就抑菌药如对羟基苯甲酸酯而言，由于生长速率常数的降低，抗菌作用导致生长迟缓。相反，诸如福尔马林防腐剂的杀菌药物不影响生长速率常数，而仅引起明显的生长迟缓。根据在两个指标的基础上绘制的两个药物效价曲线的差异，讨论了观察到的生长热谱图变化的差异。

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