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Control of legionella species and host amoeba by bis-quaternary ammonium compounds

机译：双季铵盐化合物防治军团菌和寄主变形虫的方法

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Since Legionella species, the causative organisms of Legionnaires' disease, are known to multiply in amoebal cells and survive disinfection treatments, it is necessary for biocides in order to control Legionella species to also be lethal against the host-amoeba. 4,4'-(1,6-Hexamethylenedithio) bis (1-octylpyridimium iodide) (4DTBP-6,8) and N, N'-1, 6-hexamethylenebis (1-decyl-4-carbamoylpyridinium bromide) (D-38) are the novel bis-quaternary ammonium compounds (bis-QACs), which show a wide and effective antimicrobial activity against both bacteria and fungi and exhibit low toxicity, compared with N-dodecylpyridinium iodide (P-12), a mono-QAC with a typical structure, and 2-bromo-2-nitropropane-1,3-diol (Bronopol), which has been used as a major organic biocide against Legionella species in cooling towers. The biocidal effect of these bis-QACs was investigated against Legionella species, L. pneumophila AQ 998, L. pneumophila GIFU 9134 and L. bozemanii GIFU 9140, and Acanthamoeba 96. The bis-QACs showed higher bactericidal activity against Legionella species than the comparative biocides. Amoebicidal activity was estimated by the direct cellcounting method and ATP assay based on luciferase-catalyzed reaction to assess the biocidal ability against both trophozoites and cysts. The bis-QACs, 4DTBP-6,8 and D-38, had amoebicidal activity at the concentration of 100mg/l, while the mono-QAC, P-12, had cysticidal activity above the concentration of 100mg/l, and Bronopol had no amoebicidal activity but had growth-inhibitory effect below the concentration of 100mg/l.
机译：由于军团菌是军团菌病的致病性生物，已知可在变形虫细胞中繁殖并在消毒处理中幸存下来，因此有必要使用杀生物剂来控制军团菌对宿主阿米巴具有致命性。 4,4'-（1,6-六亚甲基二硫代）双（1-辛基碘化碘鎓）（4DTBP-6,8）和N，N'-1，6-六亚甲基双（1-癸基-4-氨基甲酰基吡啶鎓溴化物）（D- 38）是新型双季铵化合物（bis-QAC），与单QAC碘化十二烷基吡啶鎓碘化物（P-12）相比，对细菌和真菌均具有广泛而有效的抗菌活性，并且毒性低。具有典型结构的2-溴-2-硝基丙烷-1,3-二醇（Bronopol），已被用作冷却塔中军团菌的主要有机杀生物剂。研究了这些bis-QAC对军团菌物种，嗜肺军团菌AQ 998，嗜肺军团菌GIFU 9134和博兹曼氏菌GIFU 9140和棘阿米巴96的杀生物作用。与对照品相比，bis-QAC对军团菌具有更高的杀菌活性。杀菌剂。通过直接细胞计数法和基于萤光素酶催化反应的ATP测定来评估杀螨活性，以评估对滋养体和囊肿的杀生物能力。 bis-QACs 4DTBP-6,8和D-38在100mg / l的浓度下具有杀菌作用，而mono-QAC P-12在100mg / l的浓度以上具有杀菌作用，而Bronopol则具有杀菌作用。浓度低于100mg / l时，无杀螨活性，但具有生长抑制作用。

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