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首页> 外文期刊>Autoimmunity >Spontaneous arthritis in MRL/lpr mice is aggravated by Staphylococcus aureus and ameliorated by Nippostrongylus brasiliensis infections.
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Spontaneous arthritis in MRL/lpr mice is aggravated by Staphylococcus aureus and ameliorated by Nippostrongylus brasiliensis infections.

机译：MRL / lpr小鼠的自发性关节炎会因金黄色葡萄球菌而加重，而巴西柔脂夜蛾感染会减轻。

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摘要

Rheumatoid arthritis is an autoimmune disease that affects human beings worldwide. Infections have been associated to autoimmune diseases because their ability to induce a dominant cytokine response. Joint inflammation has been related to Th1 response because they induce high expression of proinflammatory cytokines TNF-alpha, IL-1, IFN-gamma. MRL/lpr mice spontaneously develop an autoimmune disease affecting joints, kidneys, etc. We compared incidence and severity of arthritis, antibody response, cytokine production, in mice infected with bacteria or helminthes in the Murphy Roths Large (MRL)lpr mice. Infections with helminthes Heligmosomoides polygyrus, Nippostrongylus brasiliensis or bacteria Nocardia brasiliensis and Staphylococcus aureus were studied. IL-4, IFN-gamma and IgG1, IgG2a antibody productions were determined. IFN-gamma was increased in all groups, the highest production was observed after bacterial infection; IL-4 production was higher after helminthes infection. IgG1 sera levels were increased in the helminthes infected group. IgG2a sera concentration was stimulated by bacterial infection. The histopathology showed that 100% of bacterial infected mice developed arthritis and severe tissue damage such as cartilage erosion and bone destruction. Animals infected with parasites showed a decreased incidence and severity of arthritis. Severity of tissue damage in joints is correlated with increased numbers of lymphocytes and macrophages immunoreactive to proinflammatory cytokines.
机译：类风湿关节炎是一种自身免疫性疾病，会影响全世界的人类。感染与自身免疫性疾病有关，因为它们具有诱导显性细胞因子应答的能力。关节发炎与Th1反应有关，因为它们诱导促炎性细胞因子TNF-α，IL-1，IFN-γ的高表达。 MRL / lpr小鼠自发性发展为一种影响关节，肾脏等的自身免疫性疾病。我们比较了在Murphy Roths Large（MRL）lpr小鼠中感染细菌或蠕虫的小鼠中关节炎的发生率和严重性，抗体反应，细胞因子产生。研究了蠕虫，多头螺旋藻，巴西夜蛾或巴西诺卡氏菌和金黄色葡萄球菌的感染。测定了IL-4，IFN-γ和IgG1，IgG2a抗体的产生。 IFN-γ在所有组中均增加，细菌感染后产生最高;蠕虫感染后，IL-4的产量较高。蠕虫感染组的IgG1血清水平升高。细菌感染刺激了IgG2a血清浓度。组织病理学表明，100％的细菌感染小鼠发展为关节炎和严重的组织损伤，例如软骨侵蚀和骨破坏。被寄生虫感染的动物显示出降低的关节炎发生率和严重程度。关节组织损伤的严重程度与对促炎细胞因子免疫反应的淋巴细胞和巨噬细胞数量增加有关。

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